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논문 기본 정보

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학술저널
저자정보
Kim, Jihyun (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Kim, Jaehoon (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Huang, Zhouchi (College of Pharmacy and Integrated Research Institute of Parmaceutical Sciences, The Catholic University of Korea) Goo, Nayeon (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Bae, Ho Jung (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Jeong, Yongwoo (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Park, Ho Jae (Department of Oriental Pharmaceutical Science, Kyung Hee University) Cai, Mudan (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Cho, Kyungnam (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Jung, Seo Yun (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Bae, Soo Kyung (College of Pharmacy and Integrated Research Institute of Parmaceutical Sciences, The Catholic University of Korea) Ryu, Jong Hoon (Department of Life and Nanopharmaceutical Science, Kyung Hee University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제27권 제3호
발행연도
2019.1
수록면
327 - 335 (9page)

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As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials have been conducted and have failed, the development of new theraphies for AD with fewer adverse effects remains a challenge. In this study, we examined the effects of Theracurmin on cognitive decline using 5XFAD mice, an AD mouse model. Theracurmin is more bioavailable form of curcumin, generated with submicron colloidal dispersion. Mice were treated with Theracurmin (100, 300 and 1,000 mg/kg) for 12 weeks and were subjected to the novel object recognition test and the Barnes maze test. Theracurmin-treated mice showed significant amelioration in recognition and spatial memories compared those of the vehicle-treated controls. In addition, the antioxidant activities of Theracurmin were investigated by measuring the superoxide dismutase (SOD) activity, malondialdehyde (MDA) and glutathione (GSH) levels. The increased MDA level and decreased SOD and GSH levels in the vehicle-treated 5XFAD mice were significantly reversed by the administration of Theracurmin. Moreover, we observed that Theracurmin administration elevated the expression levels of synaptic components, including synaptophysin and post synaptic density protein 95, and decreased the expression levels of ionized calcium-binding adapter molecule 1 (Iba-1), a marker of activated microglia. These results suggest that Theracurmin ameliorates cognitive function by increasing the expression of synaptic components and by preventing neuronal cell damage from oxidative stress or from the activation of microglia. Thus, Theracurmin would be useful for treating the cognitive dysfunctions observed in AD.
#Theracurmin #Alzheimer's disease #Recognition memory #Spatial memory #Antioxidative activity #Synaptic component

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참고문헌 (44)

참고문헌 신청
Anand P / 2007 / Bioavailability of curcumin : problems and promises / Mol. Pharm 4:807~818 Crossref Bakhtiari M / 2017 / Protective effects of flavonoids against Alzheimer’s disease-related neural dysfunctions / Biomed. Pharmacother 93:218~229 Crossref Barnes CA / 1979 / Memory deficits associated with senescence : a neurophysiological and behavioral study in the rat / J. Comp. Physiol. Psychol 93:74~104 Crossref Brown GC / 2015 / Living too long : the current focus of medical research on increasing the quantity, rather than the quality, of life is damaging our health and harming the economy / EMBO Rep 16:137~141 Crossref Calhoun ME / 1996 / Comparative evaluation of synaptophysin-based methods for quantification of synapses / J. Neurocytol 25:821~828 Crossref

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