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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제3호
- 발행연도
- 2017.5
- 수록면
- 317 - 325 (9page)
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초록· 키워드
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Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in parallel with worldwide epidemic of obesity. Reactive oxygen species (ROS) contributes to the development and progression of NAFLD. Peroxisomes play an important role in fatty acid oxidation and ROS homeostasis, and catalase is an antioxidant exclusively expressed in peroxisome. The present study examined the role of endogenous catalase in early stage of NAFLD. 8-week-old male catalase knock-out (CKO) and age-matched C57BL/6J wild type (WT) mice were fed either a normal diet (ND: 18% of total calories from fat) or a high fat diet (HFD: 60% of total calories from fat) for 2 weeks. CKO mice gained body weight faster than WT mice at early period of HFD feeding. Plasma triglyceride and ALT, fasting plasma insulin, as well as liver lipid accumulation, inflammation (F4/80 staining), and oxidative stress (8-oxo-dG staining and nitrotyrosine level) were significantly increased in CKO but not in WT mice at 2 weeks of HFD feeding. While phosphorylation of Akt (Ser473) and PGC1α mRNA expression were decreased in both CKO and WT mice at HFD feeding, GSK3β phosphorylation and Cox4-il mRNA expression in the liver were decreased only in CKO-HF mice. Taken together, the present data demonstrated that endogenous catalase exerted beneficial effects in protecting liver injury including lipid accumulation and inflammation through maintaining liver redox balance from the early stage of HFD-induced metabolic stress.
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참고문헌 (24)
참고문헌 신청
Suzuki A / 2005 / Chronological development of elevated aminotransferases in a nonalcoholic population / Hepatology 41:64~71
Hamaguchi M / 2005 / The metabolic syndrome as a predictor of nonalcoholic fatty liver disease / Ann Intern Med 143:722~728
Basaranoglu M / 2013 / From fatty liver to fibrosis : a tale of"second hit" / World J Gastroenterol 19:1158~1165
Matsuzawa-Nagata N / 2008 / Increased oxidative stress precedes the onset of high-fat dietinduced insulin resistance and obesity / Metabolism 57:1071~1077
Diehl AM / 2005 / Lessons from animal models of NASH / Hepatol Res 33:138~144
Hamaguchi M / 2005 / The metabolic syndrome as a predictor of nonalcoholic fatty liver disease / Ann Intern Med 143:722~728
Basaranoglu M / 2013 / From fatty liver to fibrosis : a tale of"second hit" / World J Gastroenterol 19:1158~1165
Matsuzawa-Nagata N / 2008 / Increased oxidative stress precedes the onset of high-fat dietinduced insulin resistance and obesity / Metabolism 57:1071~1077
Diehl AM / 2005 / Lessons from animal models of NASH / Hepatol Res 33:138~144
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