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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 134 - 144 (11page)
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초록· 키워드
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The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased with the incidence of obesity; however, the underlying mechanisms are unknown. In this study, high-resolution metabolomics (HRM) along with transcriptomics were applied on animal models to draw a mechanistic insight of NAFLD. Wild type (WT) and catalase knockout (CKO) mice were fed with normal fat diet (NFD) or high fat diet (HFD) to identify the changes in metabolic and transcriptomic profiles caused by catalase gene deletion in correspondence with HFD. Integrated omics analysis revealed that cholic acid and $3{\beta}$, $7{\alpha}$-dihydroxy-5-cholestenoate along with cyp7b1 gene involved in primary bile acid biosynthesis were strongly affected by HFD. The analysis also showed that CKO significantly changed all-trans-5,6-epoxy-retinoic acid or all-trans-4-hydroxy-retinoic acid and all-trans-4-oxo-retinoic acid along with cyp3a41b gene in retinol metabolism, and ${\alpha}/{\gamma}$-linolenic acid, eicosapentaenoic acid and thromboxane A2 along with ptgs1 and tbxas1 genes in linolenic acid metabolism. Our results suggest that dysregulated primary bile acid biosynthesis may contribute to liver steatohepatitis, while up-regulated retinol metabolism and linolenic acid metabolism may have contributed to oxidative stress and inflammatory phenomena in our NAFLD model created using CKO mice fed with HFD.
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참고문헌 (37)
참고문헌 신청
Arguello G / 2015 / Recent insights on the role of cholesterol in non-alcoholic fatty liver disease / Biochim. Biophys. Acta 1852:1765~1778
P. D. Cani / 2008 / Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice / Diabetes 57(6):1470~1481
Cavill R / 2016 / Transcriptomic and metabolomic data integration / Brief. Bioinform 17:891~901
Geraldine M Clarke / 2011 / Basic statistical analysis in genetic case-control studies / Nature Protocols 6(2):121~133
Ribal S. Darwish / 2007 / Nitrotyrosine as an Oxidative Stress Marker: Evidence for Involvement in Neurologic Outcome in Human Traumatic Brain Injury / The Journal of Trauma: Injury, Infection, and Critical Care 63(2):439~442
P. D. Cani / 2008 / Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice / Diabetes 57(6):1470~1481
Cavill R / 2016 / Transcriptomic and metabolomic data integration / Brief. Bioinform 17:891~901
Geraldine M Clarke / 2011 / Basic statistical analysis in genetic case-control studies / Nature Protocols 6(2):121~133
Ribal S. Darwish / 2007 / Nitrotyrosine as an Oxidative Stress Marker: Evidence for Involvement in Neurologic Outcome in Human Traumatic Brain Injury / The Journal of Trauma: Injury, Infection, and Critical Care 63(2):439~442
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