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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 341 - 348 (8page)
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초록· 키워드
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The basic route and mechanism for diapedesis has not
yet to be fully defined. Here we present evidence that
"cell-cell separation" between endothelial cells (ECs)
may provide a route for leukocyte diapedesis. We unexpectedly
found that extensive interaction between
peripheral blood leukocytes and ECs that were activated
by TNF-α induced the opening of EC contacts
and, surprisingly, resulted in cell-cell separation. This
event was specific to the intercellular adhesion molecules-
1 (ICAM-1)/leukocyte function- associated antigen-
1 interaction, as demonstrated by the following:
(1) ICAM-1 expression correlated with increased EC
contraction; and (2) the blocking of ICAM-1 selectively
inhibited EC separation. Thus, we suggest that
"cell-cell separation" could be a mechanism for diapedesis
in situations that may require massive leukocyte
infiltration.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Cinamon G / 2001 / Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines / Nat Immunol 2 : 515 ~ 522
Clark PR / 2007 / Increased ICAM-1 expression causes endothelial cell leakiness, cytoskeletal reorganization and junctional alterations / J Invest Dermatol 127 : 762 ~ 774
David M. Rose / 2006 / The role of the α4 integrin-paxillin interaction in regulating leukocyte trafficking / Experimental and Molecular Medicine 38 (3) : 191 ~ 195
Feng D / 1998 / Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP / J Exp Med 187 : 903 ~ 915
Gahmberg CG / 1997 / Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands / Eur J Biochem 245 : 215 ~ 232
Clark PR / 2007 / Increased ICAM-1 expression causes endothelial cell leakiness, cytoskeletal reorganization and junctional alterations / J Invest Dermatol 127 : 762 ~ 774
David M. Rose / 2006 / The role of the α4 integrin-paxillin interaction in regulating leukocyte trafficking / Experimental and Molecular Medicine 38 (3) : 191 ~ 195
Feng D / 1998 / Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP / J Exp Med 187 : 903 ~ 915
Gahmberg CG / 1997 / Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands / Eur J Biochem 245 : 215 ~ 232
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