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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 11 (11page)
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Background: Intrauterine environment plays a pivotal role in the origin of fatal diseases such as the metabolic syndrome. Diabetes is associated with low-grade inflammatory state and dysregulated adipokines production. The aim of this study is to investigate the effect of maternal diabetes on adipocytokines (adiponectin, leptin and TNF-α) production in F1 offspring in rats.
Methods: The offspring groups were as follows: F1 offspring of control mothers under control diet (CD) (CF1-CD), F1 offspring of control mothers under high caloric diet (HCD) (CF1-HCD), F1 offspring of diabetic mothers under CD (DF1-CD), and F1 offspring of diabetic mothers under HCD (DF1-HCD). Every 5 weeks post-natal, 10 pups of each subgroup were culled to obtain blood samples for biochemical analysis.
Results: The results indicate that DF1-CD and DF1-HCD groups exhibited hyperinsulinemia, dyslipidemia, insulin resistance and impaired glucose homeostasis compared to CF1-CD (p > 0.05). DF1-CD and DF1-HCD groups had high hepatic and muscular depositions of TGs. The significant elevated NEFA level only appeared in offspring of diabetic mothers that was fed HCD. DF1-CD and DF1-HCD groups demonstrated low serum levels of adiponectin, high levels of leptin, and elevated levels of TNF-α compared to CF1-CD (p > 0.05). These results reveal the disturbed metabolic lipid profile of offspring of diabetic mothers and could guide further characterization of the mechanisms involved.
Conclusion: Dysregulated adipocytokines production could be a possible mechanism for the transgenerational transmittance of diabetes, especially following a postnatal diabetogenic environment. Moreover, the exacerbating effects of postnatal HCD on NEFA in rats might be prone to adipcytokine dysregulation. Furthermore, dysregulation of serum adipokines is a prevalent consequence of maternal diabetes and could guide further investigations to predict the development of metabolic disturbances.
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참고문헌 (23)
참고문헌 신청
Aerts L / 2006 / Animal evidence for the transgenerational development of diabetes mellitus / Int J Biochem Cell Biol 38 (5) : 894 ~ 903
Boden G / 2002 / Free fatty acids in obesity and type 2 diabetes:defining their role in the development of insulin resistance and β?cell dysfunction / Eur J Clin Investig 3
Dandona P / 2004 / Inflammation: the link between insulin resistance, obesity and diabetes / Trends Immunol 25 (1) : 4 ~ 7
Delarue J / 2007 / Free fatty acids and insulin resistance / Curr Opin Clin Nutr Metab Care 10 (2) : 142 ~ 148
Fowden AL / 2006 / Intrauterine programming of physiological systems: causes and consequences / Physiology 21 (1) : 29 ~ 37
Boden G / 2002 / Free fatty acids in obesity and type 2 diabetes:defining their role in the development of insulin resistance and β?cell dysfunction / Eur J Clin Investig 3
Dandona P / 2004 / Inflammation: the link between insulin resistance, obesity and diabetes / Trends Immunol 25 (1) : 4 ~ 7
Delarue J / 2007 / Free fatty acids and insulin resistance / Curr Opin Clin Nutr Metab Care 10 (2) : 142 ~ 148
Fowden AL / 2006 / Intrauterine programming of physiological systems: causes and consequences / Physiology 21 (1) : 29 ~ 37
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