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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Thymosin β4 (Tβ4) has been recently reported to play a role in dentinogenesis by regula-ting the expression of dentin matrix proteins. Based on previous studies, it is hypo-thesized that Tβ4 is associated with the formation of the enamel matrix and thus plays an important role in ameloblast. However, there is no report on the function of Tβ4 during tooth development so far. Therefore, in this study, we aimed to investigate the expression of Tβ4 and its function in ameloblasts during mouse tooth development. Tβ4 was expressed strongly in the tooth bud at the bud stage and in the dental lamina and oral epithelium at the cap stage. In advanced bell stage at postnatal day 4, large elongated ameloblasts were observed and the expression of the Tβ4 protein was the highest, with the enamel being was thicker than that in the early bell stage. The length of ameloblasts increased from the presecretory to the secretory stage and decreased from the maturation to the protective stage. These results suggest that Tβ4 participates not only in the proliferation of oral epithelial cells during the early stage of tooth development but also regulates enamel protein secretion in ameloblasts and enamel mineralization.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Akhter M / 2005 / Possible functional involvement of thymosin beta 4 in developing tooth germ of mouse lower fi rst molar / Histochem. Cell Biol 124:207~213
Anadón R / 2001 / Differential expression of thymosins beta(4)and beta(10)during rat cerebellum postnatal development / Brain Res 894:255~265
Boyde A / 1989 / Handbook of Microscopic Anatomy / Springer :309~473
Catón J / 2005 / IGFs increase enamel formation by inducing expression of enamel mineralizing specific genes / Arch. Oral Biol 50:123~129
Cha H J / 2010 / Over-expression of thymosin beta 4 promotes abnormal tooth development and stimulation of hair growth / Int. J. Dev. Biol 54:135~140
Anadón R / 2001 / Differential expression of thymosins beta(4)and beta(10)during rat cerebellum postnatal development / Brain Res 894:255~265
Boyde A / 1989 / Handbook of Microscopic Anatomy / Springer :309~473
Catón J / 2005 / IGFs increase enamel formation by inducing expression of enamel mineralizing specific genes / Arch. Oral Biol 50:123~129
Cha H J / 2010 / Over-expression of thymosin beta 4 promotes abnormal tooth development and stimulation of hair growth / Int. J. Dev. Biol 54:135~140
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