지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background: Dapagliflozin is an oral selective inhibitor of sodium-glucose cotransporter 2(SGLT2), the kidney transporter chieflyresponsible for glucose reabsorption from the glomerular filtrate. Because this mechanism does not require the action of insulin,dapagliflozin rarely causes hypoglycemia. Dapagliflozin may affect blood glucose control as well as blood pressure and the bodyweight which are one of the cardiovascular disease risk factors. However, dehydration and ketoacidosis are reported as the sideeffects of the dapagliflozin treatment and the safety issues have been occurred. The aim of this study is to analyze the effectivenessand adverse events of dapagliflozin in Korean patients. Methods: From December 2014 to August 2015, we retrospectively reviewedthe electronic medical records of type 2 diabetes patients who were prescribed dapagliflozin at Severance Hospital. Results: A totalof 202 Korean patients were enrolled in this study. The effectiveness in the reduction of blood glucose was statisticallysignificant(p<0.001). Dapagliflozin decreased 0.74% of HbA1c after 24 weeks. Significantly more participants achieved the targetHbA1c level(HbA1c<7%) after 24 weeks(n=42, 35.3%) than before taking dapagliflozin(n=21, 17.6%). Blood pressure decreased 5.7mmHg s ystolic b lood p ressure(SBP), 1.9 mmHg d iastolic b lood p ressure(DBP) a fter 24 weeks. M ore than o ne q uarter ofparticipants(n=35, 29.4%) experienced weight loss. Most common adverse event was genitourinary symptoms. Conclusion: In thisstudy, the effectiveness of dapagliflozin in improving glycemic control, blood pressure control, and weight loss was statisticallysignificant. However, elderly and female patients, who have higher incidence of adverse events, should use dapagliflozin cautiously.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
ACCORD Study group / 2010 / Effects of intensive blood-pressure control in type 2 diabetes mellitus / N Engl J Med 362 (17) : 1575 ~ 1585
Bailey CJ / 2010 / Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-control
Bakris GL / 2004 / INVEST Investigators. Clinical outcomes in the diabetes cohort of the INternational VErapamil SR-Trandolapril study / Hypertension 44 : 637 ~ 642
Colditz GA / 1995 / Weight gain as a risk factor for clinical diabetes mellitus in women / Ann Intern Med 122 : 481 ~ 486
European Medicines Agency / / Guideline on clinical investigation of medicinal products in the treatments or prevention of diabetes mellitus
Bailey CJ / 2010 / Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-control
Bakris GL / 2004 / INVEST Investigators. Clinical outcomes in the diabetes cohort of the INternational VErapamil SR-Trandolapril study / Hypertension 44 : 637 ~ 642
Colditz GA / 1995 / Weight gain as a risk factor for clinical diabetes mellitus in women / Ann Intern Med 122 : 481 ~ 486
European Medicines Agency / / Guideline on clinical investigation of medicinal products in the treatments or prevention of diabetes mellitus
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