지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome complex. Also, Jab1 activate the c-jun gene resulted cell proliferation. Not only a powerful tumor suppressor but also regulator of apoptosis negative cdk inhibitor p27kip1 are involved in the cell cycle. This is Jab1 and p27kip1 interact with each other, Jab1 accelerate p27kip1 from nuclear to cytoplasm through ubiquitin/proteasome pathway. However, information about the relationship between Jab1 and p27kip1 is not known much. Taken together, the results of this study identify function and structure of Jab1 and p27kip1 were described in a recent article on the basis of relevant. Besides Jab1 and p27kip1 will organize the relationship between the disease and women. (J Menopausal Med 2016;22:6-8)
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Chamovitz DA / 2001 / JAB1/CSN5 and the COP9 signalosome. A complex situation / EMBO Rep 2:96~101
Schwechheimer C / 2001 / COP9 signalosome revisited: a novel mediator of protein degradation / Trends Cell Biol 11:420~426
Tomoda K / 1999 / Degradation of the cyclindependent-kinase inhibitor p27Kip1 is instigated by Jab1 / Nature 398:160~165
Chen F / 2005 / Ciglitazoneinduced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway / Cell Signal 17:1572~1577
Zhang Q / 2005 / Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells / FEBS Lett 579:3932~3940
Schwechheimer C / 2001 / COP9 signalosome revisited: a novel mediator of protein degradation / Trends Cell Biol 11:420~426
Tomoda K / 1999 / Degradation of the cyclindependent-kinase inhibitor p27Kip1 is instigated by Jab1 / Nature 398:160~165
Chen F / 2005 / Ciglitazoneinduced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway / Cell Signal 17:1572~1577
Zhang Q / 2005 / Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells / FEBS Lett 579:3932~3940
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