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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 369 - 374 (6page)
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Background/Aims: Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties.
In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. Methods: The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45, and SNU-1 were treated with various concentrations of astaxanthin. A cell viability test, cell cycle analysis, and immunoblotting were performed. Results: The viability of each cancer cell line was suppressed by astaxanthin in a dose-dependent manner with significantly decreased proliferation in KATO-III and SNU-1 cells. Astaxanthin increased the number of cells in the G0/G1 phase but reduced the proportion of S phase KATO-III and SNU-1 cells.
Phosphorylated extracellular signal-regulated kinase (ERK) was decreased in an inverse dose-dependent correlation with astaxanthin concentration, and the expression of p27kip-1 increased the KATO-III and SNU-1 cell lines in an astaxanthin dose-dependent manner. Conclusions: Astaxanthin inhibits proliferation by interrupting cell cycle progression in KATO-III and SNU-1 gastric cancer cells. This may be caused by the inhibition of the phosphorylation of ERK and the enhanced expression of p27kip-1.
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참고문헌 (30)
참고문헌 신청
Guerin M / 2003 / Haematococcus astaxanthin:applications for human health and nutrition / Trends Biotechnol 21:210~216
Hussein G / 2006 / Astaxanthin, a carotenoid with potential in human health and nutrition / J Nat Prod 69:443~449
Curek GD / 2010 / Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion / Toxicology 267:147~153
Otton R / 2010 / Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats / Chem Biol Interact 186:306~315
Mansour N / 2006 / The effect of dietary supplementation with blueberry, alpha-tocopherol or astaxanthin on oxidative stability of Arctic char (Salvelinus alpinus) semen / Theriogenology 66:373~382
Hussein G / 2006 / Astaxanthin, a carotenoid with potential in human health and nutrition / J Nat Prod 69:443~449
Curek GD / 2010 / Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion / Toxicology 267:147~153
Otton R / 2010 / Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats / Chem Biol Interact 186:306~315
Mansour N / 2006 / The effect of dietary supplementation with blueberry, alpha-tocopherol or astaxanthin on oxidative stability of Arctic char (Salvelinus alpinus) semen / Theriogenology 66:373~382
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