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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives: Alumina nanoparticles (Al2O3, Al-NPs) are used for various purposes, including as coating agentsand paint additives. Their potential toxicity has raised concern for human health. This study focuses on exploringthe toxic effects on the brain and kidneys caused by Al-NPs exposure in rats.
Methods: The animals were orally administered Al-NPs at 10, 50 and 100 mg/kg body weight for 28 daysfollowing OECD TG 407. To determine the targeted toxicity of Al-NPs, histopathological examination and geneexpression analysis were conducted on the rats.
Results: The Al-NPs treatment induced kidney tubular dilatation. In the rat cerebrums, the expressionlevels of 126 genes experienced two-fold or greater increases in response to Al-NPs, including othergenes encoding proteins involved in cell differentiation, transcription and signal transduction. In the ratkidneys, the expression levels of 152 genes also showed two-fold or greater increases in response to Al-NPs, including other genes encoding proteins involved in apoptosis, transcription and signaltransduction.
Conclusion: These results suggest that exposure to Al-NPs influences cellular signal pathways of kidney andcerebrum, and it can be a toxic indicators of nanometrials.
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참고문헌 (15)
참고문헌 신청
Shatkin JA / 2010 / Nano risk analysis : advancing the science for nanomaterials risk management / Risk Anal 30(11):1680~1687
Rittner MN / 2002 / Market analysis of nanostructured materials / Am. Ceram. Soc. Bull 81:33~26
Krewski D / 2007 / Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide / J Toxicol Environ Health B Crit Rev 10(Suppl 1):1~269
Oesterling E / 2008 / Alumina nanoparticles induce expression of endothelial cell adhesion molecules / Toxicol Lett 178(3):160~166
Zhang QL / 2011 / In vivo toxicity of nano-alumina on mice neurobehavioral profiles and the potential mechanisms / Int J Immunopathol Pharmacol 24(1 Suppl):23S~29S
Rittner MN / 2002 / Market analysis of nanostructured materials / Am. Ceram. Soc. Bull 81:33~26
Krewski D / 2007 / Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide / J Toxicol Environ Health B Crit Rev 10(Suppl 1):1~269
Oesterling E / 2008 / Alumina nanoparticles induce expression of endothelial cell adhesion molecules / Toxicol Lett 178(3):160~166
Zhang QL / 2011 / In vivo toxicity of nano-alumina on mice neurobehavioral profiles and the potential mechanisms / Int J Immunopathol Pharmacol 24(1 Suppl):23S~29S
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