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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objectives: The purpose of this study was to compare permeation characteristics in three skin types using oil-soluble benzoic acid and water-soluble caffeine after method condition optimization based on OECD guideline 428. Methods: A Franz diffusion cell, a reliable alternative method for skin permeation, was used. One-milliliter samples were taken and immediately replaced with fresh solution in the receptor chamber at regular time intervals (1, 2, 4, 7, 10 and 24 hr). The amount of test substances was measured by LC-MS/MS. Results: The permeation rate increased dose-dependently, and the permeation orders were KeraSkin > hairless TMmouse full skin > human cadaver epidermis for skin types, and benzoic acid solution > caffeine solution > benzoic acid cream > caffeine cream for type of test materials. Conclusion: According to the definitions of Marzulli, benzoic acid and caffeine would be classified as ‘fast’ and ‘moderate’ compared with the permeation of other chemical species. The setting conditions and permeation characteristics performed in this study are expected to contribute to future permeation studies.
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참고문헌 (24)
참고문헌 신청
Ackermann K / 2010 / The Phenion full-thickness skin model for percutaneous absorption testing / Skin Pharmacol Physiol 23 : 105 ~ 112
Barber ED / 1995 / The percutaneous absorption of hydroquinone (HQ) through rat and human skin in vitro / Toxicol Lett 80 : 167 ~ 172
Brain KR / 2005 / Percutaneous penetration of diethanolamine through human skin in vitro: application from cosmetic vehicles / Food Chem Toxicol 43 : 681 ~ 690
Chilcott RP / 2005 / In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig /
Elias PM / 2003 / Fitzpatrick’s dermatology in general medicine / McGraw-Hill
Barber ED / 1995 / The percutaneous absorption of hydroquinone (HQ) through rat and human skin in vitro / Toxicol Lett 80 : 167 ~ 172
Brain KR / 2005 / Percutaneous penetration of diethanolamine through human skin in vitro: application from cosmetic vehicles / Food Chem Toxicol 43 : 681 ~ 690
Chilcott RP / 2005 / In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig /
Elias PM / 2003 / Fitzpatrick’s dermatology in general medicine / McGraw-Hill
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