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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 52 - 52 (1page)
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Caffeine is one of the most widely consumed pharmacologically active products worldwide. Caffeine exhibits various pharmacological activities in central nervous, cardiovascular, and respiratory systems. Additionally, caffeine exhibited anti-inflammatory effects in lipopolysaccharide-challenged rats. However, the potential anti-inflammatory activity of caffeine in allergic rhinitis (AR) has not been investigated yet. Therefore, we aimed to examine the anti-allergic effects of caffeine in ovalbumin (OVA)-induced AR mice in this study.
Briefly, BALB/c mice were sensitized and challenged with OVA. Caffeine (5, 10, 20 mg/kg) and dexamethasone (Dex, 2.5 mg/kg) were treated by intranasal instillation of 20 µL/nasal cavity for 13 days.
In this study, caffeine attenuated the nasal symptoms, including rubbing and sneezing. Caffeine ameliorated the inflammation in the lungs. In addition, caffeine reduced the^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10587937');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
Briefly, BALB/c mice were sensitized and challenged with OVA. Caffeine (5, 10, 20 mg/kg) and dexamethasone (Dex, 2.5 mg/kg) were treated by intranasal instillation of 20 µL/nasal cavity for 13 days.
In this study, caffeine attenuated the nasal symptoms, including rubbing and sneezing. Caffeine ameliorated the inflammation in the lungs. In addition, caffeine reduced the^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10587937');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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UCI(KEPA) : I410-ECN-0101-2021-511-001942132