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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제51권 제3호
- 발행연도
- 2021.1
- 수록면
- 311 - 316 (6page)
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Purpose Although pharmaceutical excipients do not affect the membrane permeation of active drugs, some have been shown to influence absorption-regulating factors. However, limited information is currently available on the effects of pharmaceutical excipients on membrane permeation via passive transcellular transport, which is the main membrane permeation route of many drugs. Methods We herein focused on polyvinylpyrrolidone (PVP) (K90), which is used as a diluent and binder in pharmaceutical formulations, and examined its effects on passive transport via the transcellular route in the rat jejunum using the in vitro sac method. Results The membrane permeation of β-naphthol, a passive transcellular marker, was increased by the co-existence of 0.02 w/v % PVP (K90). However, PVP (K90)-induced increases in membrane permeation were not observed following a pre-incubation with PVP (K90). Therefore, PVP (K90)-induced increases in membrane permeation may be attributed to a drug-excipient interaction, but not a mucosal membrane-excipient interaction. Conclusion PVP (K90) affected membrane transport via the transcellular route in the rat jejunum. However, since the coexistence of PVP (K90) did not influence membrane protein expression levels or cause membrane lesions, the absorption of active drugs may be regulated by the optimal application of PVP (K90).
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참고문헌 (13)
참고문헌 신청
Bromberg L / 2003 / Effects of polyether-modified poly (acrylic acid) microgels on doxorubicin transport in human intestinal epithelial Caco-2 cell layers / J Control Release 88:11~22
Collnot EM / 2007 / Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity / Mol Pharm 4:465~474
Cornaire G / 2004 / Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo / Int J Pharm 278:119~131
Kavimandan NJ / 2006 / Novel delivery system based on complexation hydrogels as delivery vehicles for insulintransferrin conjugates / Biomaterials 27:3846~3854
Kim YS / 2010 / Intestinal goblet cells and mucins in health and disease: recent insights and progress / Curr Gastroenterol Rep 12:319~330
Collnot EM / 2007 / Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity / Mol Pharm 4:465~474
Cornaire G / 2004 / Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo / Int J Pharm 278:119~131
Kavimandan NJ / 2006 / Novel delivery system based on complexation hydrogels as delivery vehicles for insulintransferrin conjugates / Biomaterials 27:3846~3854
Kim YS / 2010 / Intestinal goblet cells and mucins in health and disease: recent insights and progress / Curr Gastroenterol Rep 12:319~330
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