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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제46권 제7호
- 발행연도
- 2016.12
- 수록면
- 677 - 684 (8page)
이용수
초록· 키워드
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Ondansetron was formulated into a transdermal matrix patch to reduce side effects and improve patient compliance. The effects of adhesive (polyisobutylene rubber, acrylic, and styrene butadiene rubber), crosslinker content (aluminum), vehicle (lactic acid), and drug amount on ondansetron skin permeation rate were investigated using excised hairless mouse skin with a flow-through diffusion cell system. Acrylic adhesive resulted in a higher ondansetron permeation rate than that of other adhesives.
The ondansetron matrix patch prepared with acrylic adhesive without the crosslinker showed the highest permeation rate of 0.92 lg/cm2/h. Adding the crosslinker to the matrix patch reduced ondansetron skin permeation rate. The molecular weight and functional group of adhesive did not affect skin permeation of ondansetron from the matrix patch. As the amount of ondansetron in the matrix patch was increased (2.0?6.5 %), skin permeation rate increased up to 5 % of the drug, which was unchanged beyond this concentration. Based on these results, the optimum formulation for an ondansetron matrix patch consisted of 5 % ondansetron, 5 % lactic acid, 19.9 % N-methyl-2-pyrrolidone, 5 % ethyl oleate, 2 % glycerol monooleate, and 63.1 % acrylic adhesive (SK 1570-50F). This optimized matrix patch resulted in a skin permeation rate of 1.01 ± 0.21 lg/cm2/h through excised hairless mouse skin.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Ahmad Z. / 2009 / Novel preparation of transdermal drug-delivery patches and functional wound healing materials / J Drug Target 17:724~729
Akhlaq M. / 2016 / Formulation and evaluation of anti-rheumatic dexibuprofen transdermal patches : a quality-by-design approach / J Drug Target 24(7):603~612
Bathe RS. / 2015 / Transdermal drug delivery system : formulation, development and evaluation-An overview / Int J of Biomed Adv Res 6:1~10
Butcher M / 1993 / Global experience with ondansetron and future potential / Oncology 50:191~197
Can AS. / 2013 / Optimization and characterization of chitosan films for transdermal delivery of ondansetron / Molecules 18:5455~5471
Akhlaq M. / 2016 / Formulation and evaluation of anti-rheumatic dexibuprofen transdermal patches : a quality-by-design approach / J Drug Target 24(7):603~612
Bathe RS. / 2015 / Transdermal drug delivery system : formulation, development and evaluation-An overview / Int J of Biomed Adv Res 6:1~10
Butcher M / 1993 / Global experience with ondansetron and future potential / Oncology 50:191~197
Can AS. / 2013 / Optimization and characterization of chitosan films for transdermal delivery of ondansetron / Molecules 18:5455~5471
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