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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국잠사학회 International Journal of Industrial Entomology International Journal of Industrial Entomology 제35권 제1호
- 발행연도
- 2017.1
- 수록면
- 7 - 13 (7page)
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초록· 키워드
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In this study, changes in gene expression after administration of silk fibroin fragments (size ≈ 30 kDa) were evaluated in MG63 cells using a cDNA microarray assay. In addition, the level of alkaline phosphatase (ALP) activity and cellular proliferation in the group administered moderately sized silk fibroin fragments (size ≈ 30 kDa) (MSF) were compared to those in the group administered smaller silk fibroin fragments (size < 1 kDa) (SSF). The results of the cDNA microarray assay show increased expression of genes that are related to the cell cycle and inflammation. ALP, bone morphogenetic protein-7, bone morphogenetic protein receptor type IA, and runt-related transcription factor 2 exhibited significantly lower expression compared to control cells (fold ratio < 0.5). Relative ALP activity of the 100 μg/mL MSF group was significantly lower than that of the SSF group (P < 0.05). Thus, the MSF group showed increased expression of genes associated with cellular proliferation and inflammation but decreased expression of genes associated with osteogenesis.
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참고문헌 (18)
참고문헌 신청
Aaron H. Morris / 2017 / The host response to naturally-derived extracellular matrix biomaterials / Seminars in Immunology 29 : 72 ~ 91
B?t?iosu M / 2015 / Effects of therapy with two combinations of antibiotics on the imbalance of MMP-2÷TIMP-2 in chronic periodontitis / Rom J Morphol Embryol 56 : 77 ~ 83
Brown J / 2015 / Impact of silk biomaterial structure on proteolysis / Acta Biomater 11 : 212 ~ 221
Cao Y / 2009 / Biodegradation of silk biomaterials / Int J Mol Sci 10 : 1514 ~ 1524
Chae-Kyung Yoo / 2016 / Cell attachment and proliferation of osteoblast-like MG63 cells on silk fibroin membrane for guided bone regeneration / Maxillofacial Plastic Reconst
B?t?iosu M / 2015 / Effects of therapy with two combinations of antibiotics on the imbalance of MMP-2÷TIMP-2 in chronic periodontitis / Rom J Morphol Embryol 56 : 77 ~ 83
Brown J / 2015 / Impact of silk biomaterial structure on proteolysis / Acta Biomater 11 : 212 ~ 221
Cao Y / 2009 / Biodegradation of silk biomaterials / Int J Mol Sci 10 : 1514 ~ 1524
Chae-Kyung Yoo / 2016 / Cell attachment and proliferation of osteoblast-like MG63 cells on silk fibroin membrane for guided bone regeneration / Maxillofacial Plastic Reconst
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