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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background/Aims: Renal aging-related changes are characterized by oxidative stress. SIRT1 regulates cellular conditions by activating Nrf2. The present study investigated the processes of renal changes by antioxidant enzymes and the relationship between SIRT1 and Nrf2. Methods: We used male 2-, 12-, and 24-month-old C57BL/6 mice. We measured renal function, histological changes, oxidative stress, and expression of SIRT1–Nrf2 signaling in the kidneys. Results: 24-month-old mice exhibited increased albuminuria and serum creatinine. Creatinine clearance was decreased in 24-month-old mice compared with 12-month-old mice. There were increases in mesangial volume and tubulointerstitial fibrosis in 24-month-old mice. Moreover, oxidative stress marker, 3-Nitrotyrosine, expression and apoptosis were increased in 24-month-old mice. The 24 h urinary 8-isoprostane and 8-hydroxy-deoxyguanosine excretion increased with aging. The levels of expression of SIRT1 and nuclear Nrf2 were decreased in 24-month-old mice. The antioxidant enzymes HO-1 and NQO-1 were down-regulated in 24-month-old mice. Another antioxidant enzyme, SOD2, was decreased in 24-month-old mice. Conclusions: Our results demonstrated that SIRT1 was down-regulated with aging, and this may be related to changes in the expression of target molecules including Nrf2. As a result, oxidative stress was induced. The pharmacological targeting of these signaling molecules may reduce the pathological changes associated with aging in the kidney.
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참고문헌 (25)
참고문헌 신청
Alpers CE / 2011 / Mouse models of diabetic nephropathy / Curr Opin Nephrol Hypertens 20 : 278 ~ 284
Bowen RL / 2004 / Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones / Gerontology 50 : 265 ~ 290
Harman D / 2006 / Free radical theory of aging: an update: increasing the functional life span / Ann N Y Acad Sci 1067 : 10 ~ 21
He W / 2010 / Sirt1 activation protects the mouse renal medulla from oxidative injury / J Clin Invest 120 : 1056 ~ 1068
Hill GS / 2003 / Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation / Kidney Int 63 : 1027 ~ 1036
Bowen RL / 2004 / Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones / Gerontology 50 : 265 ~ 290
Harman D / 2006 / Free radical theory of aging: an update: increasing the functional life span / Ann N Y Acad Sci 1067 : 10 ~ 21
He W / 2010 / Sirt1 activation protects the mouse renal medulla from oxidative injury / J Clin Invest 120 : 1056 ~ 1068
Hill GS / 2003 / Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation / Kidney Int 63 : 1027 ~ 1036
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