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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 486 - 490 (5page)
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초록· 키워드
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Primary penile melanomas are rare tumors that represent less than 0.1% of all melanomas. We report a case of a 60-year-old Japanese male with a mucosal penile melanoma and describe an increased CD8+ T cell infiltration in brain after dacarbazine (DTIC) administration. After partial penectomy and left inguinal lymphadenectomy, he developed multiple lung, bone, spleen, brain and skin metastases. He was treated with interferon-β, DTIC and nivolumab.
However, the metastases were not reduced in size. Immunohistochemistry showed an increase of CD8+ T cell infiltration and programmed death-ligand 1 (PD-L1) expression after the administration of DTIC, but the expression of programmed cell death protein 1 (PD-1) was negative. We speculate that DTIC exerted immunostimulatory effects, but nivolumab was ineffective due to the negative expression of PD-1 and/or an insufficient infiltration of CD8+ T cells. Although this is only one case, this case report could be the first step to discuss the development of effective therapies against melanoma to take advantage of the increased CD8+ T cell infiltration elicited by chemotherapeutic agents. It would be beneficial to pay more attention to the relationship between DTIC and immune checkpoint modulators.
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참고문헌 (8)
참고문헌 신청
Oliva E. / 2000 / Primary malignant melanoma of the urethra : a clinicopathologic analysis of 15 cases / Am J Surg Pathol 24:785~796
Ugurel S. / 2013 / Dacarbazine in melanoma : from a chemotherapeutic drug to an immunomodulating agent / J Invest Dermatol 133:289~292
Müller P. / 2014 / Cancer chemotherapy agents target intratumoral dendritic cells to potentiate antitumor immunity / Oncoimmunology 3:e954460
Hervieu A. / 2013 / Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth / J Invest Dermatol 133:499~508
Hirano F. / 2005 / Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity / Cancer Res 65:1089~1096
Ugurel S. / 2013 / Dacarbazine in melanoma : from a chemotherapeutic drug to an immunomodulating agent / J Invest Dermatol 133:289~292
Müller P. / 2014 / Cancer chemotherapy agents target intratumoral dendritic cells to potentiate antitumor immunity / Oncoimmunology 3:e954460
Hervieu A. / 2013 / Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth / J Invest Dermatol 133:499~508
Hirano F. / 2005 / Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity / Cancer Res 65:1089~1096
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