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Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells
Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한면역학회 Immune Network Immune Network Vol.15 No.2 KCI Accredited Journals SCIE
- 발행연도
- 2015.4
- 수록면
- 58 - 65 (8page)
이용수
Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells
초록· 키워드
오류제보하기
Melanoma is the most aggressive skin cancer and its incidence is gradually increasing worldwide. Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of ＜16%). In the last few years, several drugs have been approved for malignant melanoma, such as tyrosine kinase inhibitors and immune checkpoint blockades. Although new therapeutic agents have improved progression-free and overall survival, their use is limited by drug resistance and drug-related toxicity. At the same time, adoptive cell therapy of metastatic melanoma with tumor-infiltrating lymphocytes has shown promising results in preclinical and clinical studies. In this review, we summarize the currently available drugs for treatment of malignant melanoma. In addition, we suggest cytokine-induced killer (CIK) cells as another candidate approach for adoptive cell therapy of melanoma. Our preclinical study and several previous studies have shown that CIK cells have potent anti-tumor activity against melanomas in vitro and in an in vivo human tumor xenograft model without any toxicity.
목차
INTRODUCTION
CURRENT TREATMENT OF MALIGNANT MELANOMA
ADOPTIVE CELL THERAPY OF MELANOMA WITH TUMOR-INFILTRATING LYMPHOCYTES
ADOPTIVE CELL THERAPY OF MELANOMA WITH NATURAL KILLER CELLS
ADOPTIVE CELL THERAPY OF MELANOMA WITH CYTOKINE-INDUCED KILLER CELLS
CONCLUSION
REFERENCES
참고문헌 (68)
참고문헌 신청
1. [학술지(정기간행물)] - Gordon, R. / 2013 / Skin cancer: an overview of epidemiology and risk factors / Semin. Oncol. Nurs 29 : 160 ~ 169
2. [학술지(정기간행물)] - Lomas, A. / 2012 / A systematic review of worldwide incidence of nonmelanoma skin cancer / Br. J. Dermatol 166 : 1069 ~ 1080
3. [학술지(정기간행물)] - Gray-Schopfer, V. / 2007 / Melanoma biology and new targeted therapy / Nature 445 : 851 ~ 857
4. [학술지(정기간행물)] - Marks, R. / 2000 / Epidemiology of melanoma / Clin. Exp. Dermatol 25 : 459 ~ 463
5. [학술지(정기간행물)] - Whiteman, D. C. / 2001 / Childhood sun exposure as a risk factor for melanoma : a systematic review of epidemiologic studies / Cancer Causes Control 12 : 69 ~ 82
2. [학술지(정기간행물)] - Lomas, A. / 2012 / A systematic review of worldwide incidence of nonmelanoma skin cancer / Br. J. Dermatol 166 : 1069 ~ 1080
3. [학술지(정기간행물)] - Gray-Schopfer, V. / 2007 / Melanoma biology and new targeted therapy / Nature 445 : 851 ~ 857
4. [학술지(정기간행물)] - Marks, R. / 2000 / Epidemiology of melanoma / Clin. Exp. Dermatol 25 : 459 ~ 463
5. [학술지(정기간행물)] - Whiteman, D. C. / 2001 / Childhood sun exposure as a risk factor for melanoma : a systematic review of epidemiologic studies / Cancer Causes Control 12 : 69 ~ 82
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UCI(KEPA) : I410-ECN-0101-2016-511-001746295