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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 183 - 190 (8page)
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Background: Vitamin B12 deficiency has been associated with peripheral neuropathy, loss of sensation in the peripheral nerves, and weakness in the lower extremities. Methylcobalamin is the most effective analogue of vitamin B12 used to treat or prevent the complications associated with vitamin B12 deficiency. The current study aimed to compare the serum cobalamin levels after administration of two different regimes of methylcobalamin in peripheral neuropathy patients.Methods: The present study was a prospective, randomized, comparative study. The study consisted of two parallel groups, group A (methylcobalamin 500 g injection intramuscularly three times a week) and group B (methylcobalamin 1500 g injection intramuscularly once a week). A control group of healthy volunteers was also included. Results: A total of 24 patients (12 in each group) were included in the study. Five healthy volunteers were also included as a control in each group. At the end of treatment, serum cobalamin levels were significantly (P = 0.028) higher in group A (1892.08 ± 234.50) as compared with group B (1438.5 ± 460.32). The serum cobalamin levels in Group A healthy volunteers were also two times higher than that of group B (P = 0.056). Both the LANSS scale and DN4 questionnaire reported similar results at end of treatment.Conclusions: The 500 g methylcobalamin thrice weekly regime is more effective in increasing the serum cobalamin levels as compared to the 1500 g methylcobalamin once weekly regime. (Korean J Pain 2018; 31: 183-190)
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참고문헌 (33)
참고문헌 신청
Zagar BR / 2014 / Evaluating the association between vitamin B12 deficiency and peripheral neuropathy in patients with diabetes / Int J Med Pharm 2:1~10
Briani C / 2013 / Cobalamin deficiency: clinical picture and radiological findings / Nutrients 5:4521~4539
Oh R / 2003 / Vitamin B12 deficiency / Am Fam Physician 67:979~986
Leishear K / 2012 / Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults / J Am Geriatr Soc 60:1057~1063
Healton EB / 1991 / Neurologic aspects of cobalamin deficiency / Medicine (Baltimore) 70:229~245
Briani C / 2013 / Cobalamin deficiency: clinical picture and radiological findings / Nutrients 5:4521~4539
Oh R / 2003 / Vitamin B12 deficiency / Am Fam Physician 67:979~986
Leishear K / 2012 / Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults / J Am Geriatr Soc 60:1057~1063
Healton EB / 1991 / Neurologic aspects of cobalamin deficiency / Medicine (Baltimore) 70:229~245
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