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자료유형
학술저널
저자정보
저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제30권 제5호
발행연도
2016.1
수록면
326 - 334 (9page)

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Purpose: To evaluate the long-term clinical effectiveness and safety of corneal collagen cross-linking (CXL) inprogressive keratoconus compared with untreated contralateral eyes. Methods: In this retrospective study, nine eyes of nine patients with progressive keratoconus who receivedCXL (treatment group) and nine untreated contralateral eyes with keratoconus (control group) were included. All patients were followed for at least 5 years and assessed with best-corrected visual acuity, maximumkeratometry, mean keratometry, corneal astigmatism, and corneal thickness. Clinical data were collectedpreoperatively and at 1, 3, 6, 12, 24, 36, 48, and 60 months, postoperatively. Results: Mean best-corrected visual acuity improved significantly from 0.58 ± 0.37 logarithm of minimum angleof resolution preoperatively to 0.39 ± 0.29 logarithm of minimum angle of resolution at 5 years after cornealCXL (p = 0.012). There was significant flattening of the maximum keratometry and mean keratometry frompreoperative values of 63.39 ± 10.89 and 50.87 ± 6.27 diopter (D) to postoperative values of 60.89 ± 11.29 and49.54 ± 7.23 D, respectively (p = 0.038, 0.021). Corneal astigmatism decreased significantly from 7.20 ± 1.83D preoperatively to 5.41 ± 1.79 D postoperatively (p = 0.021). The thinnest corneal thickness decreased from434.00 ± 54.13 to 365.78 ± 71.58 μm during 1 month after treatment, then increased to 402.67 ± 52.55 μm at 5years, which showed a statistically significant decrease compared to the baseline (p = 0.020). In the untreatedcontralateral eyes, mean keratometry increased significantly at 2 years compared with the baseline (p = 0.043). Conclusions: CXL seems to be an effective and safe treatment for halting the progression of keratoconus overa long-term follow-up period of up to 5 years in progressive keratoconus.

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