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ObjectiveTo investigate the change of maternal characteristics, delivery and neonatal outcomes in gestational diabetes mellitus(GDM) over recent 10 years and to identify the risk factors associated with adverse outcome. MethodsConsecutive GDM patients (n=947) delivered in our institution were included. Research period was arbitrarily dividedinto 2 periods (period 1: from 2006 to 2010, period 2: from 2011 to 2015). Multiple pregnancies or preexisting diabeteswere excluded. Maternal baseline characteristics, delivery and neonatal outcomes were reviewed. Fetal biometricfindings by prenatal ultrasonography were collected. Adverse pregnancy outcome (APO) was defined by the presenceof one of the followings; shoulder dystocia, neonatal macrosomia (>4 kg), neonatal hypoglycemia (<35 mg/dL),respiratory distress syndrome (RDS), and admission to the neonatal intensive care unit (NICU) in term pregnancy. ResultsPeriod 2 was associated with older maternal age (34 vs. 33, P<0.001) and higher proportion of GDM A2 compared toperiod 1 (30.9% vs. 23.0%, P=0.009). By univariate analysis, APO was associated with increased body mass index (BMI)at pre-pregnancy (23.4 kg/m2 vs. 21.8 kg/m2, P=0.001) or delivery (27.9 kg/m2 vs. 25.8 kg/m2, P<0.001), higher HbA1c atdiagnosis (5.6% vs. 5.3%, P<0.001) or delivery (5.8% vs. 5.5%, P=0.044), and larger fetal biometric findings (abdominalcircumference [AC] and estimated fetal weight, P=0.029 and P=0.007, respectively). Multivariate analysis showed prepregnancyBMI (odds ratio [OR], 1.101; 90% confidence interval [CI], 1.028–1.180) and fetal AC (OR, 1.218; 90% CI,1.012–1.466) were independently associated with adverse outcomes. ConclusionOur study demonstrated the trends and relevant factors associated with the adverse outcomes.

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