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논문 기본 정보

자료유형
학술저널
저자정보
Hydar El Jamaly (Department of Gastroenterology and Hepatology Nepean Hospital) Guy D Eslick (Hunter Medical Research Institute The University of Newcastle) Martin Weltman (Department of Gastroenterology and Hepatology Nepean Hospital)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제28권 제1호
발행연도
2022.1
수록면
52 - 66 (15page)
DOI
10.3350/cmh.2021.0205

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Background/Aims: Maternal and fetal outcomes in pregnant patients with Non-alcoholic fatty liver disease (NAFLD) have been largely unexplored. To determine the level of evidence associated with maternal and fetal outcomes in pregnant women with NAFLD. Methods: We conducted a comprehensive literature search. The studies included pregnant patients with a previous, current or subsequent diagnosis of NAFLD. We used a random-effects model using odds ratios (OR) with 95% confidence intervals (CI). Results: Twenty-two studies, with 13,641 female NAFLD patients were reviewed. The results highlight that NAFLD patients had a statistically significant increased likelihood of baseline diabetes mellitus (OR, 6.00; 95% CI, 2.21?16.31; P<0.001; n=7), baseline Hypertension (OR, 3.75; 95% CI, 2.13?6.59; P<0.001; n=4), gestational hypertension (OR, 1.83; 95% CI, 1.03?3.26; P=0.041; n=2), and pre-eclampsia (OR, 2.43; 95% CI, 1.46?4.04; P=0.001; n=3). The odds for a past and current history of gestational diabetes mellitus were OR, 3.78; 95% CI, 2.21?6.44; P<0.001; n=5 and OR, 3.23; 95% CI, 1.97? 5.31; P<0.001; n=6, respectively. As for fetal outcomes, pregnant NAFLD patients were significantly more likely to have a premature birth (OR, 2.02; 95% CI, 1.44?2.85; P<0.001; n=4), large for gestational age birth (OR, 2.01; 95% CI, 1.72?2.37; P<0.001; n=2) or a history of prior miscarriage or abortion (OR, 1.15; 95% CI, 1.02?1.30; P=0.02; n=2). Egger’s regression revealed no evidence of publication bias (P>0.05). Conclusions: This meta-analysis provides pooled evidence that NAFLD is associated with a substantial increase in maternal diabetic and hypertensive complications and multiple adverse fetal outcomes. This data is important for clinicians managing these patients before, during and after pregnancy.

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