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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 46 - 54 (9page)
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초록· 키워드
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PURPOSE Osteosarcoma occurring in the head and neck region is known as a malignant tumor that shows a relatively poor prognosis and, despite various treatments, clinicians have often been confounded by it. The existence or non-existence of the mutation of the gene p16INK4a has been used in prognosis assessment. In this study, author have attempted to determine whether methylation of the gene p16INK4a could be applied to forecast the progress of osteosarcomas in the head and neck region having been given poor prognoses in the diagnostic process and the early stage of treatment.
RESEARCH SUBJECT AND METHOD
Clinicopathologic investigations, immunohistochemical examinations, a methylation specific polymerase reaction (MSP) analysis, and a survival analysis were conducted on the tissues of 20 patients with mandibulofacial osteosarcoma.
RESULTS
Neither age, sex, size, smoking or non-smoking, nor region have showed a statistical significance with methylation or unmethylation of the gene p16INK4a and expression rates demonstrated by immunohisto- chemical examinations. A chi-square test indicated that recurrence inclination has no relation with the expression rate of p16 protein (p=0.6615), but it showed a statistical significance with methylation of the gene p16INK4a (p=0.0033). With respect to investigations of the survival rates, a Kaplan-Meier survival analysis found that the manifestation rate of p16 protein did not have an impact on survival (p=0.8864), but that the methylation of the gene p16INK4a resulted in significant differences in survival rates (p=0.0105).
CONCLUSIONS
The above results show that methylation of the gene p16INK4a could be one of the major factors that help determine the recurrence inclination
and prognosis of osteosarcomas occurring in the head and neck region.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] -
/ / Effects of DNA methylation on DNAbinding proteins and gene expression : 226 ~ 231
/ 1995 / 5’CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancer 1 : 686 ~ 692
/ 1995 / Homozygous deletion of the CDKN2 gene in human sarcomas: relationship to amplification and mRNA levels of CDK4 and CCND1 72 : 393 ~ 398
/ 1995 / Immunohistochemical detction of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4a in archival human solid tumor
/ / Effects of DNA methylation on DNAbinding proteins and gene expression : 226 ~ 231
/ 1995 / 5’CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancer 1 : 686 ~ 692
/ 1995 / Homozygous deletion of the CDKN2 gene in human sarcomas: relationship to amplification and mRNA levels of CDK4 and CCND1 72 : 393 ~ 398
/ 1995 / Immunohistochemical detction of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4a in archival human solid tumor
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