지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제44권 제6호
- 발행연도
- 2010.1
- 수록면
- 623 - 630 (8page)
이용수
초록· 키워드
오류제보하기
Background : Study on epigenetics of urothelial carcinomas has expanded and allowed better understanding of their correlation with clinicopathologic features. The aim of this study was to determine reliable predictive epigenetic markers for patients with urothelial carcinoma of urinary bladder. Methods : In 64 urothelial carcinomas of the urinary bladder, methylationspecific polymerase chain reaction with RAS association domain family 1A (RASSF1A), adenomatous polyposis coli (APC), death-associated protein-kinase (DAPK), runt-related transcription factor 3 (RUNX3), p14, p16 and MGMT was performed and correlated the results with p53 mutations, DNA ploidy, clinicopathologic parameters and recurrences. Results : Hypermethyation of RASSF1A, APC, DAPK, RUNX3, p14, p16 and MGMT promoters was observed in 35 (54.7%), 29 (45.3%), 18 (28.1%), 18 (28.1%), 9 (14.1%), 2 (3.1%), and 6 (9.4%) cases, respectively. Hypermethylation of RUNX3 and APC was significantly associated with high histologic grades and aneuploidy. Methylation of DAPK was significantly associated with muscle invasion. Methylation of DAPK and RUNX3 genes was significantly associated with recurrence. In survival analyses, methylation of RUNX3 gene and methylation-high (methylation at two or more loci) phenotype was significantly associated with poor recurrence-free survival. Conclusions : Methylation of RUNX3 gene and methylation-high phenotype are significant indicator of recurrence.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Amaral JD / 2010 / The role of p53 in apoptosis / Discov Med 9 : 145 ~ 152
Brait M / 2008 / Aberrant promoter methylation of multiple genes during pathogenesis of bladder cancer / Cancer Epidemiol Biomarkers Prev 17 : 2786 ~ 2794
Catto JW / 2005 / Promoter hypermethylation is associated with tumor location,stage,and subsequent progression in transitional cell carcinoma / J Clin Oncol 23 : 2903 ~ 2910
Chan MW / 2002 / Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients / Clin Cancer Res 8 : 464 ~ 470
Dulaimi E / 2004 / Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel / Clin Cancer Res 10 : 1887 ~ 1893
Brait M / 2008 / Aberrant promoter methylation of multiple genes during pathogenesis of bladder cancer / Cancer Epidemiol Biomarkers Prev 17 : 2786 ~ 2794
Catto JW / 2005 / Promoter hypermethylation is associated with tumor location,stage,and subsequent progression in transitional cell carcinoma / J Clin Oncol 23 : 2903 ~ 2910
Chan MW / 2002 / Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients / Clin Cancer Res 8 : 464 ~ 470
Dulaimi E / 2004 / Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel / Clin Cancer Res 10 : 1887 ~ 1893
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유방암에서 종양억제 유전자(Tumor Suppressor Gene)의 메틸화(Methylation)에 관한 임상연구
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