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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 123 - 127 (5page)
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Interleukin-32 (IL-32) is a cytokine inducing crucial inflammatory cytokines such as tumor necrosis factor-α(TNFα) and IL-6 and its expression is elevated in various inflammatory autoimmune diseases, certain cancers, as well as viral infections. IL-32 gene was first cloned from activated T cells, however IL-32 expression was also found in other immune cells and non-immune cells. IL-32 gene was identified in most mammals except rodents. It is transcribed as multiple-spliced variants in the absence of a specific activity of each isoform. IL-32 has been studied mostly in clinical fields such as infection, autoimmune, cancer, vascular disease, and pulmonary diseases. It is difficult to investigate the precise role of IL-32 in vivo due to the absence of IL-32 gene in mouse. The lack of mouse IL-32 gene restricts in vivo studies and restrains further development of IL-32 research in clinical applications although IL-32 new cytokine getting a spotlight as an immune regulatory molecule processing important roles in autoimmune, infection, and cancer. In this review, we discuss the regulation and function of IL-32 in inflammatory bowel diseases and rheumatoid arthritis.
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참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Netea, M. G. / 2005 / IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism / Proc. Natl. Acad. Sci. USA 102 : 16309 ~ 16314
2. [학술지(정기간행물)] - Imaeda, H. / 2011 / A new isoform of interleukin-32 suppresses IL-8 mRNA expression in the intestinal epithelial cell line HT-29 / Mol. Med. Rep 4 : 483 ~ 487
3. [학술지(정기간행물)] - Shioya, M. / 2007 / Epithelial overexpression of interleukin- 32alpha in inflammatory bowel disease / Clin. Exp. Immunol 149 : 480 ~ 486
4. [학술지(정기간행물)] - Ciccia, F. / 2012 / Increased expression of interleukin-32 in the inflamed ileum of ankylosing spondylitis patients / Rheumatology (Oxford) 51 : 1966 ~ 1972
5. [학술지(정기간행물)] - Andoh, A. / 2008 / Mucosal cytokine network in inflammatory bowel disease / World J. Gastroenterol 14 : 5154 ~ 5161
2. [학술지(정기간행물)] - Imaeda, H. / 2011 / A new isoform of interleukin-32 suppresses IL-8 mRNA expression in the intestinal epithelial cell line HT-29 / Mol. Med. Rep 4 : 483 ~ 487
3. [학술지(정기간행물)] - Shioya, M. / 2007 / Epithelial overexpression of interleukin- 32alpha in inflammatory bowel disease / Clin. Exp. Immunol 149 : 480 ~ 486
4. [학술지(정기간행물)] - Ciccia, F. / 2012 / Increased expression of interleukin-32 in the inflamed ileum of ankylosing spondylitis patients / Rheumatology (Oxford) 51 : 1966 ~ 1972
5. [학술지(정기간행물)] - Andoh, A. / 2008 / Mucosal cytokine network in inflammatory bowel disease / World J. Gastroenterol 14 : 5154 ~ 5161
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