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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 120 - 124 (5page)
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초록· 키워드
오류제보하기
Osteonecrosis of the jaw (ONJ) is commonly described as an adverse effect of the use of bisphosphonates. A few cases of ONJ associated with tyrosine kinase inhibitors (sunitinib, imatinib) have been reported in the literature and usually they occurred in patients simultaneously treated with bisphosphonates.
We report an atypical case of ONJ related only to imatinib. A 72-year-old male patient was treated with imatinib for metastases from gastrointestinal stromal tumors (GISTs). The patient developed ONJ after 22 months of imatinib only therapy. During his whole life, the patient had never been treated with bisphosphonates or radiotherapy. Microscope examination of the tissues confirmed the clinical diagnosis of diffuse osteonecrosis and showed absence of neoplastic cells. Thus, secondary localisations from GISTs were ruled out. Osteonecrosis of the lower jaw appeared 22 months after initial and exclusive therapy with imatinib. Therefore, imatinib monotherapy can induce ONJ in patients that have never been treated with bisphosphonates or radiotherapy.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Abramson RG / 2013 / Complications of targeted drug therapies for solid malignancies:manifestations and mechanisms / AJR Am J Roentgenol 200 : 475 ~ 483
Beuselinck B / 2012 / Concomitant oral tyrosine kinase inhibitors and bisphosphonates in advanced renal cell carcinoma with bone metastases / Br J Cancer 107 : 1665 ~ 1671
Dulucq S / 2010 / The pharmacogenetics of imanitib / Genome Med 2 : 85 ~
Fleissig Y / 2012 / Sunitinib related osteonecrosis of jaw: a case report / Oral Surg Oral Med Oral Pathol Oral Radiol 113 : e1 ~ e3
Joensuu H / 2001 / Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor / N Engl J Med 344 : 1052 ~ 1056
Beuselinck B / 2012 / Concomitant oral tyrosine kinase inhibitors and bisphosphonates in advanced renal cell carcinoma with bone metastases / Br J Cancer 107 : 1665 ~ 1671
Dulucq S / 2010 / The pharmacogenetics of imanitib / Genome Med 2 : 85 ~
Fleissig Y / 2012 / Sunitinib related osteonecrosis of jaw: a case report / Oral Surg Oral Med Oral Pathol Oral Radiol 113 : e1 ~ e3
Joensuu H / 2001 / Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor / N Engl J Med 344 : 1052 ~ 1056
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