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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Bisphosphonates are the most widely prescribed drugs for the treatment of osteoporosis, and are also used in malignant bone metastases, multiple myeloma, and Paget’s disease, and provide therapeutic efficacy on those diseases. However, it was reported that occurrence of osteonecrosis of the jaw (ONJ) could be related with bisphosphonate exposures, and there have been many cases regarding this issue. Therefore, a clearer definition and treatment guidelines were needed for this disease. The American Society for Bone and Mineral Research (ASBMR) and American Association of Oral and Maxillofacial Surgeons (AAOMS) reported statements on bisphosphonate-related ONJ (BRONJ), and a revised version was recently presented. In the revised edition, the diagnosis BRONJ was changed to medication-related ONJ (MRONJ), which reflects a consideration of the fact that ONJ also occurs for denosumab, a bone resorption inhibitor of the receptor activator of nuclear factor-kappa B ligand (RANKL) antibody family, and bevacizumab, an antiangiogenesis inhibitor. In 2009, a statement on ONJ was also reported locally by a relevant organization, which has served as basis for clinical treatment in Korea. In addition to the new official stance of the AAOMS and ASBMR, with an increasing pool of ONJ clinical experience, a revised version of the 2009 local statement is needed. As such, the Korean Society for Bone and Mineral Research (KSBMR) and the Korean Association of Oral and Maxillofacial Surgeons (KAOMS) have collectively formed a committee for the preparation of an official statement on MRONJ, and have reviewed recent local and international data to propose guidelines customized for the local Korean situation.
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참고문헌 (20)
참고문헌 신청
Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws / 2007 / American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-re
Amadori D / 2013 / Efficacy and safety of 12-weekly versus 4-weekly zoledronic acid for prolonged treatment of patients with bone metastases from breast cancer (ZOOM): a pha
Aragon-Ching JB / 2009 / Higher incidence of Osteonecrosis of the Jaw(ONJ)in patients with metastatic castration resistant prostate cancer treated with anti-angiogenic agents
Assaf AT / 2013 / Incidence of bisphosphonate-related osteonecrosis of the jaw in consideration of primary diseases and concomitant therapies / Anticancer Res 33 : 3917 ~ 392
Bamias A / 2005 / Osteonecrosis of the jaw in cancer after treatment with bisphosphonates : incidence and risk factors / J Clin Oncol 23 : 8580 ~ 8587
Amadori D / 2013 / Efficacy and safety of 12-weekly versus 4-weekly zoledronic acid for prolonged treatment of patients with bone metastases from breast cancer (ZOOM): a pha
Aragon-Ching JB / 2009 / Higher incidence of Osteonecrosis of the Jaw(ONJ)in patients with metastatic castration resistant prostate cancer treated with anti-angiogenic agents
Assaf AT / 2013 / Incidence of bisphosphonate-related osteonecrosis of the jaw in consideration of primary diseases and concomitant therapies / Anticancer Res 33 : 3917 ~ 392
Bamias A / 2005 / Osteonecrosis of the jaw in cancer after treatment with bisphosphonates : incidence and risk factors / J Clin Oncol 23 : 8580 ~ 8587
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