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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 588 - 593 (6page)
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초록· 키워드
오류제보하기
There are increasing reports regarding regeneration of the defected tissues using tissue engineering technique. In this technique, multipotential stem cells are essential. There are many potential sources of adult stem cells, such as bone marrow, umbilical cord blood, fat, muscle, dental tissues and skin. Among them, skin is highly accessible and easily obtained with a minimum of donor site complications. Moreover, skin is an abundant adult stem cell sources and has the potential for self-replication and immune privilege. In this study, we isolated skin-derived precursor cells (SKPs) from the ear of adult miniature pigs. In these SKPs, the expression of transcriptional factors, Oct-4, Sox-2, and Nanog were detected by RT-PCR. In vitro osteogenesis and adipogenesis were observed at 3 weeks after transdifferentiations as assayed by positive von Kossa and Oil-red O staining, respectively.
In addition, expression of osteocalcin and osteonectin in the osteogenic differentiation medium and PPARγ2 and aP2 in the adipogenic differentiation medium were detected by RT-PCR. In vitro neurogenesis of porcine SKPs was observed during 24 and 72 hours after treatment of neurogenic differentiation medium. The results of this study suggest that SKPs demonstrate the properties of pluripotence or multipotence and multi-lineage differentiation. This indicates that autogenous SKPs are a reliable and useful source of adult stem cells for regenerative medicine.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Avilion AA / 2003 / Multipotent cell lineages in early mouse development depend on Sox2 function / Genes Dev 17 : 126 ~ 140
Boyer LA / 2005 / Core transcriptional regulatory circuitry in human embryonic stem cells / Cell 122 : 947 ~ 956
Bucher P / 2005 / Xenotransplantation: an update on recent progress and future perspectives / Transpl Int 18 : 894 ~ 901
Buranasinsup S / 2006 / In vitro osteogenesis from skin-derived precursor cells / Develop Growth Differ 48 : 263 ~ 269
Carlin R / 2006 / Expression of early transcription factors Oct-4, Sox-2 and Nanog by porcine umbilical cord (PUC) matrix cells / Reprod Biol Endocrinol 4 : 8 ~ 20
Boyer LA / 2005 / Core transcriptional regulatory circuitry in human embryonic stem cells / Cell 122 : 947 ~ 956
Bucher P / 2005 / Xenotransplantation: an update on recent progress and future perspectives / Transpl Int 18 : 894 ~ 901
Buranasinsup S / 2006 / In vitro osteogenesis from skin-derived precursor cells / Develop Growth Differ 48 : 263 ~ 269
Carlin R / 2006 / Expression of early transcription factors Oct-4, Sox-2 and Nanog by porcine umbilical cord (PUC) matrix cells / Reprod Biol Endocrinol 4 : 8 ~ 20
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Modification of Pluripotency and Neural Crest-Related Genes' expression in Murine Skin-Derived Precursor Cells by Leukemia Inhibitory Factor (LIF)
International Journal of Oral Biology
2012 .01
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Stemness and Proliferation of Murine Skin-Derived Precursor Cells under Hypoxic Environment
International Journal of Oral Biology
2016 .01
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신규 합성 $K_{ATP}$ 통로 개방제인 SKP-450과 대사체 SKP-818의 흰쥐 적출 심장 및 대동맥에 대한 작용
약학회지
1997 .01
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고혈압 치료제 SKP-450의 유전독성평가 ( Genotoxicity Studies of an Antihypertensive Agent, SKP-450 )
한국환경성돌연변이·발암원학회지
1998 .09
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$K^+$ Channel 개방제인 SKP-450의 신장작용
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2000 .01
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Dental tissues as adult stem cell source
대한구강악안면외과학회지
2013 .01
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Effect of Valproic acid, a Histone Deacetylase Inhibitor, on the Expression of Pluripotency and Neural Crest Specific Marker Genes in Murine Multipotent Skin Precursor Cells
International Journal of Oral Biology
2010 .01
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MicroRNA-186 targets SKP2 to induce p27Kip1-mediated pituitary tumor cell cycle deregulation and modulate cell proliferation
The Korean Journal of Physiology & Pharmacology
2019 .01
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미성숙 매복지치의 치낭, 치수, 치근유두 조직에서 다능성 줄기세포의 분리와 특성화에 대한 연구
대한구강악안면외과학회지
2010 .01
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$K^+$ Channel 개방제인 SKP-450의 신장작용에 대한 신장 신경제거와 ATP-의존성 $K^+$ Channel 차단제인 Glibenclamide의 영향
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2000 .01
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Arsenic Trioxide Inhibits Cell Growth and Invasion via Down-Regulation of Skp2 in Pancreatic Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Inhibition of SKP2 Sensitizes Bromocriptine-Induced Apoptosis in Human Prolactinoma Cells
Cancer Research and Treatment
2017 .01
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Differential Potential of Stem Cells Following Their Origin : Subacromial Bursa, Bone Marrow, Umbilical Cord Blood
대한견주관절의학회지
2012 .12
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줄기세포 치료의 최신 지견
Obstetrics & Gynecology Science
2005 .01
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Adult Stem Cell Therapy for Stroke: Challenges and Progress
대한뇌졸중학회지
2016 .01
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Stem Cells in Plastic Surgery: A Review of Current Clinical and Translational Applications
Archives of plastic surgery : APS
2013 .01
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귀에 존재하는 내인성 성체줄기세포
대한이비인후-두경부외과학회지
2013 .01
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In vitro Differentiation of Human Umbilical Cord-derived Stem Cells and Human Amnion-derived Stem Cells into Hepatocyte-like Cells
대한생식의학회 학술대회
2007 .01
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In vitro Neuronal Cell Differentiation Derived from Human Carcinoma Stem Cells
대한생식의학회 학술대회
2007 .01
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