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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 69 - 74 (6page)
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Skin-derived precursors (SKPs) have potential to differentiate to various cell types including osteoblasts, adipocytes and neurons. SKPs are a candidate for cell-based therapy since they are easily accessible and have multipotency. Most mammalian cells are exposed to a low oxygen environment with 1 to 5% O2 concentration in vivo, while 21% O2 concentration is common in in vitro culture. The difference between in vitro and in vivo O2 concentration may affect to the behavior of cultured cells.
In this report, we investigated the effect of hypoxic condition on stemness and proliferation of SKPs. The results indicated that SKPs exposed to hypoxic condition for 5 days showed no change in proliferation. In terms of mRNA expression, hypoxia maintained expression of stemness markers; whereas, oncogenes, such as Klf4 and c-Myc, were downregulated, and the expression of Nestin, related to cancer migration, was also downregulated. Thus, SKPs cultured in hypoxia may reduce the risk of cancer in SKP cell-based therapy.
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참고문헌 (40)
참고문헌 신청
Jeffrey A Biernaskie / 2007 / Isolation of skin-derived precursors (SKPs) and differentiation and enrichment of their Schwann cell progeny / Nature Protocols 1(6):2803~2812
Jean G. Toma / 2001 / Isolation of multipotent adult stem cells from the dermis of mammalian skin / Nature Cell Biology 3(9):778~784
J A Kim / 2015 / Neural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer’s disease mouse model / Cell Death and Disease 6(6):e1789
Seung U. Kim / 2013 / Neural stem cell-based treatment for neurodegenerative diseases / Neuropathology
Shuchai Xu / 2015 / Effect of mesenchymal stromal cells for articular cartilage degeneration treatment: a meta-analysis / Cytotherapy 17(10):1342~1352
Jean G. Toma / 2001 / Isolation of multipotent adult stem cells from the dermis of mammalian skin / Nature Cell Biology 3(9):778~784
J A Kim / 2015 / Neural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer’s disease mouse model / Cell Death and Disease 6(6):e1789
Seung U. Kim / 2013 / Neural stem cell-based treatment for neurodegenerative diseases / Neuropathology
Shuchai Xu / 2015 / Effect of mesenchymal stromal cells for articular cartilage degeneration treatment: a meta-analysis / Cytotherapy 17(10):1342~1352
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