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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제8호
- 발행연도
- 2009.1
- 수록면
- 787 - 791 (5page)
이용수
초록· 키워드
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In the course of screening for substances that inhibit
etoposide (10 μg/ml)-induced apoptosis in human leukemia
U937 cells, fungal strain F000120, which exhibits potent
inhibitory activity, was selected. The active compound was
purified from an ethyl acetate extract of the microorganism
by Sep-pak C18 column chromatography and HPLC, and
was identified as heptelidic acid (koningic acid) by
spectroscopic methods. This compound inhibited caspase-
3 induction in U937 cells with an IC50 value of 40 μM after
8 h of etoposide treatment. Fluorescent dye staining with
acridine orange and ethidium bromide showed that
heptelidic acid inhibited apoptosis. Furthermore, it was
found that DNA fragmentation and caspase-3 activation,
the biological hallmarks of apoptosis, were inhibited by
the compound in a dose-dependent manner, suggesting
that heptelidic acid inhibits etoposide-induced apoptosis
via downregulation of caspases.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Agrawal, S. / 2002 / Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis / Mol. Cell Biol 22 : 1981 ~ 1992
Budihardjo, I. / 1999 / Biochemical pathways of caspase activation during apoptosis / Annu. Rev. Cell Dev. Biol 15 : 269 ~ 290
Ching, J. C. / 2002 / Escherichia coli Shiga-like toxins induce apoptosis and cleavage of poly (ADP-ribose) polymerase via in vitro activation of caspases / Infect. Immun 70
Dove, A. / 2001 / Making a living out of the art of dying / Nat. Biotechnol 19 : 615 ~ 619
Endo, A. / 1985 / Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid) / J. Antibiot. (Tokyo) 38 : 920 ~ 925
Budihardjo, I. / 1999 / Biochemical pathways of caspase activation during apoptosis / Annu. Rev. Cell Dev. Biol 15 : 269 ~ 290
Ching, J. C. / 2002 / Escherichia coli Shiga-like toxins induce apoptosis and cleavage of poly (ADP-ribose) polymerase via in vitro activation of caspases / Infect. Immun 70
Dove, A. / 2001 / Making a living out of the art of dying / Nat. Biotechnol 19 : 615 ~ 619
Endo, A. / 1985 / Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid) / J. Antibiot. (Tokyo) 38 : 920 ~ 925
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