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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제3호
- 발행연도
- 2009.1
- 수록면
- 286 - 290 (5page)
이용수
초록· 키워드
오류제보하기
In the course of screening for substances inhibiting apoptosis
of U937 human leukemia cells induced by etoposide (10 µg/ml),
Forsythiae fructus, which showed a high level of inhibition,
was selected. The regulating compounds were purified from
the ethyl acetate extract by silica gel column chromatography
and HPLC. The active substance was purified and identified
as rengyolone by spectroscopic methods. This compound
showed inhibitory activity on caspase-3 induction, a major
protease of the apoptosis cascade, with an IC50 value of
38.96 µM after 8 h of etoposide treatment in U937 cells.
The expression level of caspase-3 and poly(ADP-ribose)
polymerase (PARP) were dose-dependently inhibited by the
compound, suggesting that rengyolone inhibits etoposideinduced
apoptosis via downregulation of caspases.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alfaro, C. / 2003 / Screening for metabolites from Penicillium novae-zeelandiae displaying radical-scavenging activity and oxidative mutagenicity: Isolation of gentisyl alcoh
Bae, M. A. / 1998 / Aburnatubolactam C, a novel apoptosis-inducing substance produced by marine Streptomyces sp. SCRC A-20 / J. Microbiol. Biotechnol 8 : 455 ~ 460
Bhunia, A. K. / 1999 / Examination of cytopathic effect and apoptosis in Listeria monocytogenes-infected hybridoma B-lymphocyte (Ped-2E9) line in vitro / J. Microbiol. Biotec
Bradford, M. M. / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 7
Cavalieri, E. / 2004 / Alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells / Biochem. Biophys. Res. Commun 315 : 589 ~ 594
Bae, M. A. / 1998 / Aburnatubolactam C, a novel apoptosis-inducing substance produced by marine Streptomyces sp. SCRC A-20 / J. Microbiol. Biotechnol 8 : 455 ~ 460
Bhunia, A. K. / 1999 / Examination of cytopathic effect and apoptosis in Listeria monocytogenes-infected hybridoma B-lymphocyte (Ped-2E9) line in vitro / J. Microbiol. Biotec
Bradford, M. M. / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 7
Cavalieri, E. / 2004 / Alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells / Biochem. Biophys. Res. Commun 315 : 589 ~ 594
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