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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제17권 제11호
- 발행연도
- 2007.1
- 수록면
- 1,856 - 1,861 (6page)
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Physiological cell conditions such as glucose
deprivation and hypoxia play roles in the development of drug
resistance in solid tumors. These tumor-specific conditions
cause decreased expression of DNA topoisomerase IIα,
rendering cells resistant to topo II target drugs such as
etoposide. Thus, targeting tumor-specific conditions such as a
low glucose environment may be a novel strategy in the
development of anticancer drugs. On this basis, we established
a novel screening program for anticancer agents with
preferential cytotoxic activity in cancer cells under glucosedeprived
conditions. We recently isolated an active compound,
AA-98, from Streptomyces sp. AA030098 that can prevent
stress-induced etoposide resistance in vitro. Furthermore, LCMS
and various NMR spectroscopic methods identified AA-
98 as mithramycin, which belongs to the aureolic acid group
of antitumor compounds. We found that mithramycin prevents
the etoposide resistance that is induced by glucose deprivation.
The etoposide-chemosensitive action of mithramycin was just
dependent on strict low glucose conditions, and resulted in the
selective cell death of etoposide-resistant HT-29 human colon
cancer cells.
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