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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제9호
- 발행연도
- 2009.1
- 수록면
- 946 - 950 (5page)
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초록· 키워드
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In the course of screening for apoptotic substances that
induce apoptosis in human leukemia U937 cells, a fungal
strain, F000487, which exhibits potent inducible activity,
was selected. The active compound was purified from an
ethyl acetate extract of the microorganism by Sep-pak C18
column chromatography and HPLC, and was identified
as atromentin by spectroscopic methods. This compound
induced caspase-3 processing in human leukemia U937
cells. The caspase-3 and poly (ADP-ribose) polymerase
(PARP) were induced by atromentin in a dose-dependent
manner. Furthermore, DNA fragmentation was also
induced by this compound in a dose-dependent manner.
These results show that atromentin potently induces
apoptosis in U937 cells and that atromentin-induced
apoptosis is related to the selective activation of caspases.
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참고문헌 (25)
참고문헌 신청
Bhalla, K. / 1993 / High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells / Blood 82 : 3133 ~ 3140
Bradham, C. A. / 1998 / The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release / Mol. Cell. Biol 18
Choi, S. K. / 2007 / Saucernetin-7 isolated from Saururus chinensis induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells / Biol. Pharm. Bull 30 : 1
Dantzer, F. / 1999 / Involvement of poly(ADP ribose) polymerase in base excission repair / Biochimie 81 : 69 ~ 75
De Almeida, C. J. / 2005 / Phagocytosis of apoptotic cells: A matter of balance / Cell Mol. Life Sci 62 : 1532 ~ 1546
Bradham, C. A. / 1998 / The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release / Mol. Cell. Biol 18
Choi, S. K. / 2007 / Saucernetin-7 isolated from Saururus chinensis induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells / Biol. Pharm. Bull 30 : 1
Dantzer, F. / 1999 / Involvement of poly(ADP ribose) polymerase in base excission repair / Biochimie 81 : 69 ~ 75
De Almeida, C. J. / 2005 / Phagocytosis of apoptotic cells: A matter of balance / Cell Mol. Life Sci 62 : 1532 ~ 1546
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