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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제9호
- 발행연도
- 2018.1
- 수록면
- 1,563 - 1,572 (10page)
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Gold nanoparticles (AuNP) and their conjugates have been gaining a great deal of recognition in the medical field. Meanwhile, extended-spectrum β-lactamases (ESBL)-producing bacteria are also demonstrating a challenging problem for health care. The aim of this study was the biosynthesis of AuNP using Rosa damascenes petal extract and conjugation of ceftriaxone antibiotic (Cef-AuNP) in inhibiting ESBL-producing bacteria and study of in vitro anticancer activity. Characterization of the synthesized AuNP and Cef-AuNP was studied. ESBLproducing strains, Acinetobacter baumannii ACI1 and Pseudomonas aeruginosa PSE4 were used for testing the efficacy of Cef-AuNP. The cells of MCF-7 breast cancer were treated with previous AuNP and Cef-AuNP at different time intervals. Cytotoxicity effects of apoptosis and its molecular mechanism were evaluated. Ultraviolet-visible spectroscopy and Fourier transform infrared spectroscopy established the formation of AuNP and Cef-AuNP. Transmission electron microscope demonstrated that the formed nanoparticles were of different shapes with sizes of 15~35 nm and conjugation was established by a slight increase in size. Minimum inhibitory concentration (MIC) values of Cef-AuNP against tested strains were obtained as 3.6 and 4 μg/ml, respectively. Cef-AuNP demonstrated a decrease in the MIC of ceftriaxone down to more than 27 folds on the studied strains. The biosynthesized AuNP displayed apoptotic and time-dependent cytotoxic effects in the cells of MCF-7 at a concentration of 0.1 μg/ml medium. The Cef-AuNP have low significant effects on MCF-7 cells. These results enhance the conjugating utility in old unresponsive ceftriaxone with AuNP to restore its efficiency against otherwise resistant bacterial pathogens. Additionally, AuNP may be used as an alternative chemotherapeutic treatment of MCF-7 cancer cells.
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참고문헌 (41)
참고문헌 신청
Litake GM GV / 2015 / Phenotypic ESBL detection in Acinetobacter baumannii: a real challenge / Am. J. Infect. Dis. 11:48~53
LB R / 2010 / Progress and challenges in implementing the research on ESKAPE pathogens / Infect. Control Hospital Epidemiol. 31:S7~S10
Centers for Disease Control and Prevention (CDC) / 2013 / Antibiotic resistance threats in the United States
Paterson DL BR / 2005 / Extended-spectrum beta-lactamases: a clinical update / Clin. Microbiol. Rev. 18:657~686
Mishra SK RB / 2013 / Emerging threat of multidrug resistant bugs-Acinetobacter calcoaceticus baumannii complex and methicillin resistant Staphylococcus aureus / BMC Res. Notes 6:98~103
LB R / 2010 / Progress and challenges in implementing the research on ESKAPE pathogens / Infect. Control Hospital Epidemiol. 31:S7~S10
Centers for Disease Control and Prevention (CDC) / 2013 / Antibiotic resistance threats in the United States
Paterson DL BR / 2005 / Extended-spectrum beta-lactamases: a clinical update / Clin. Microbiol. Rev. 18:657~686
Mishra SK RB / 2013 / Emerging threat of multidrug resistant bugs-Acinetobacter calcoaceticus baumannii complex and methicillin resistant Staphylococcus aureus / BMC Res. Notes 6:98~103
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