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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제4호
- 발행연도
- 2017.1
- 수록면
- 701 - 708 (8page)
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초록· 키워드
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This study was conducted to evaluate the hyaluronidase (HAase) inhibition activity of Asparagus cochinchinesis (AC) extracts following fermentation by Weissella cibaria through response surface methodology. To optimize the HAase inhibition activity, a central composite design was introduced based on four variables: the concentration of AC extract (X1: 1–5%), amount of starter culture (X2: 1–5%), pH (X3: 4–8), and fermentation time (X4: 0–10 days). The experimental data were fitted to quadratic regression equations, the accuracy of the equations was analyzed by ANOVA, and the regression coefficients for the surface quadratic model of HAase inhibition activity in the fermented AC extract were estimated by the F test and the corresponding p values. The HAase inhibition activity indicated that fermentation time was most significant among the parameters within the conditions tested. To validate the model, two different conditions among those generated by the Design Expert program were selected. Under both conditions, predicted and experimental data agreed well. Moreover, the content of protodioscin (a well-known compound related to anti-inflammation activity) was elevated after fermentation of the AC extract at the optimized fermentation condition.
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참고문헌 (24)
참고문헌 신청
Cameron E / 1979 / Ascorbic acid and cancer: a review / Cancer Res 39 : 663 ~ 681
Choo DY / 2009 / Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation / J. Ethnopharmacol 121 : 28 ~ 34
Elson LA / 1933 / A colorimetric method for the determination of glucosamine and chondrosamine / Biochem. J 27 : 1824 ~ 1828
Fusco V / 2015 / The genus Weissella: taxonomy, ecology and biotechnological potential / Front. Microbiol 6 : 155 ~
Girish KS / 2007 / The magic glue hyaluronan and its eraser hyaluronidase: a biological overview / Life Sci 80 : 1921 ~ 1943
Choo DY / 2009 / Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation / J. Ethnopharmacol 121 : 28 ~ 34
Elson LA / 1933 / A colorimetric method for the determination of glucosamine and chondrosamine / Biochem. J 27 : 1824 ~ 1828
Fusco V / 2015 / The genus Weissella: taxonomy, ecology and biotechnological potential / Front. Microbiol 6 : 155 ~
Girish KS / 2007 / The magic glue hyaluronan and its eraser hyaluronidase: a biological overview / Life Sci 80 : 1921 ~ 1943
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