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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제3호
- 발행연도
- 2017.1
- 수록면
- 542 - 551 (10page)
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초록· 키워드
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Small phytochemicals have been successfully adopted as antibacterial chemotherapies and are being increasingly viewed as potential antibiofilm agents. Some of these molecules are known to repress biofilm and toxin production by certain bacterial and yeast pathogens, but information is lacking with regard to the genes allied with biofilm formation. The present study was performed to investigate the inhibitory effect of burdock root extract (BRE) and of chlorogenic acid (CGA; a component of BRE) on clinical isolates of Klebsiella pneumoniae. BRE and CGA exhibited significant antibiofilm activity against K. pneumoniae without inflicting any harm to its planktonic counterparts. In vitro assays supported the β-lactamase inhibitory effect of CGA and BRE while in silico docking showed that CGA bound strongly with the active sites of sulfhydryl-variable-1 β-lactamase. Furthermore, the mRNA transcript levels of two biofilmassociated genes (type 3 fimbriae mrkD and trehalose-6-phosphate hydrolase treC) were significantly downregulated in CGA- and BRE-treated samples. In addition, CGA inhibited biofilm formation by Escherichia coli and Candida albicans without affecting their planktonic cell growth. These findings show that BRE and its component CGA have potential use in antibiofilm strategies against persistent K. pneumoniae infections.
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참고문헌 (22)
참고문헌 신청
Bakkiyaraj D / 2012 / Inhibition of quorum sensing
Bakkiyaraj D / 2013 / The anti-biofilm potential of pomegranate (Punica granatum L.) extract against human bacterial and fungal pathogens / Biofouling 29 : 929 ~ 937
Balestrino D / 2008 / The characterization of functions involved in the establishment and maturation of Klebsiella pneumoniae in vitro biofilm reveals dual roles for surface
Boddicker JD / 2006 / Signature-tagged mutagenesis of Klebsiella pneumoniae to identify genes that influence biofilm formation on extracellular matrix material / Infect. Imm
Chan YS / 2011 / A review of the pharmacological effects of Arctium lappa (burdock) / Inflammopharmacology 19 : 245 ~ 254
Bakkiyaraj D / 2013 / The anti-biofilm potential of pomegranate (Punica granatum L.) extract against human bacterial and fungal pathogens / Biofouling 29 : 929 ~ 937
Balestrino D / 2008 / The characterization of functions involved in the establishment and maturation of Klebsiella pneumoniae in vitro biofilm reveals dual roles for surface
Boddicker JD / 2006 / Signature-tagged mutagenesis of Klebsiella pneumoniae to identify genes that influence biofilm formation on extracellular matrix material / Infect. Imm
Chan YS / 2011 / A review of the pharmacological effects of Arctium lappa (burdock) / Inflammopharmacology 19 : 245 ~ 254
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