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학술저널
저자정보
Nyanasegran Pravin Kumran (Institute of Systems Biology Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor Malaysia) Nathan Sheila (Faculty of Science and Technology Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor Malaysia) Firdaus-Raih Mohd (Institute of Systems Biology Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor MalaysiaFaculty of Science and Technology Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor Malaysia) Muhammad Nor Azlan Nor (Institute of Systems Biology Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor Malaysia) Ng Chyan Leong (Institute of Systems Biology Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor Malaysia)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제33권 제1호
발행연도
2023.1
수록면
15 - 27 (13page)
DOI
10.4014/jmb.2207.07032

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The incidence of melioidosis cases caused by the gram-negative pathogen Burkholderia pseudomallei (BP) is seeing an increasing trend that has spread beyond its previously known endemic regions. Biofilms produced by BP have been associated with antimicrobial therapy limitation and relapse melioidosis, thus making it urgently necessary to understand the mechanisms of biofilm formation and their role in BP biology. Microbial cells aggregate and enclose within a self-produced matrix of extracellular polymeric substances (EPSs) to form biofilm. The transition mechanism of bacterial cells from planktonic state to initiate biofilm formation, which involves the formation of surface attachment microcolonies and the maturation of the biofilm matrix, is a dynamic and complex process. Despite the emerging findings on the biofilm formation process, systemic knowledge on the molecular mechanisms of biofilm formation in BP remains fractured. This review provides insights into the signaling systems, matrix composition, and the biosynthesis regulation of EPSs (exopolysaccharide, eDNA and proteins) that facilitate the formation of biofilms in order to present an overview of our current knowledge and the questions that remain regarding BP biofilms.

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