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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제2호
- 발행연도
- 2010.1
- 수록면
- 438 - 445 (8page)
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초록· 키워드
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The immunomodulatory effects of Aureobasidium pullulans SM-2001 exopolymers containing β-1,3/1,6-glucan were evaluated in cyclophosphamide (CPA)-treated mice. To induce immunosuppression, 150 and 110 mg/kg of CPA were intraperitoneally injected 3 days and 1 day, respectively,before beginning administration of the test material.
Exopolymers were delivered subcutaneously or orally, four times, in a volume of 10 ml/kg at 12-h intervals beginning 24 h after the second CPA treatment. Changes in thymus and spleen weights, splenic amounts of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-10, and numbers of CD3+, CD4+, CD8+, and TNF-α+ thymus and spleen cells were monitored in CPA-treated mice. As a result of CPA treatment, dramatic decreases in the number of CD3+,CD4+, CD8+, and TNF-α+ cells were detected in the thymus and spleen, along with decreases in thymus and spleen weights. In addition, splenic TNF-α, IL-1β, and IL-10 contents were also decreased on observation with flow cytometry. However, oral and subcutaneous treatments with exopolymers effectively reduced the immunosuppressive changes induced by CPA. Therefore, it is concluded that exopolymers of A. pullulans SM-2001 can effectively prevent immunosuppression through, at least partially,the recruitment of T cells and TNF-α+ cells or enhancement of their activity, and can provide an effective component of prevention or treatment regimens for immunosuppression related to cancer, sepsis, and high-dose chemotherapy or radiotherapy.
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참고문헌 (24)
참고문헌 신청
Angulo, I / 2000 / Nitric oxideproducing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+ cells in the spleen of cyclophosphamide-treated mice: Implications for Tcell responses in immunosupp
Benach, J. L / 1982 / Glucan as an adjuvant for a murine Babesia microti immunization trial / Infect. Immun 35 : 947 ~ 951
Browder, I. W / 1984 / Modification of post-operative C. albicans sepsis by glucan immunostimulation / Int. J. Immunopharmacol 6 : 19 ~ 26
Burnet, M / 1995 / The helper T-cell responses in Immunology, an Introduction / Saunders : 139 ~ 154
Chirigos, M. A / 1978 / Chemical and biological adjuvants capable of potentiating tumor cell vaccine / Cancer Res 38 : 1085 ~ 1091
Benach, J. L / 1982 / Glucan as an adjuvant for a murine Babesia microti immunization trial / Infect. Immun 35 : 947 ~ 951
Browder, I. W / 1984 / Modification of post-operative C. albicans sepsis by glucan immunostimulation / Int. J. Immunopharmacol 6 : 19 ~ 26
Burnet, M / 1995 / The helper T-cell responses in Immunology, an Introduction / Saunders : 139 ~ 154
Chirigos, M. A / 1978 / Chemical and biological adjuvants capable of potentiating tumor cell vaccine / Cancer Res 38 : 1085 ~ 1091
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