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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 717 - 722 (6page)
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This study explored the effects of low-dose and high-dose irradiation on inflammatory macrophage cells, specifically inflammatory cytokine secretion and nitric oxide (NO) production after irradiation. To elucidate the effect of irradiation on active and inactive macrophages, we exposed LPS-treated or untreated murine monocyte/macrophage RAW 264.7 cell lines to low-dose to high-dose radiation (0.01–10 Gy).Weanalyzed the effects of irradiation onRAW 264.7 cell proliferation byMTT assays and analyzed cytokine secretion and NO production related to inflammation by ELISA assays. Low-to-high doses of radiation did not significantly affect the proliferation of LPS-treated or untreated RAW 264.7 cells. Pro-inflammatory cytokine IL-1ß was generally increased in RAW 264.7 cells at 3 days after radiation. Especially, IL-1ß was significantly increased in only high dose-irradiation (2 and 10 Gy irradiation) groups in LPSuntreated RAW264.7 cells but increased in both lowand high dose-irradiation groups (0.01–10 Gy) in LPS-treated RAW 264.7 cells at 3 days after irradiation.Whereas, the expression of IL-1ß was prolonged in high-dose irradiation group at 5 days after irradiation. The production of anti-inflammatory cytokine IL-10 did not change significantly at 3 days after radiation but was significantly reduced at 5 days after 10 Gy radiation. The effect of irradiation on the secretion of IL-1ß and IL-10 was not significantly different between RAW264.7 cells treated or not treated with LPS. The effect of irradiation on NO secretion by RAW 264.7 cells showed a specific pattern. NO was produced after low-dose irradiation but reduced in a high-dose irradiation group at 3 days after irradiation. However, NO production was not changed after low-dose irradiation and reduced at 5 days after high-dose irradiation. These results showed that irradiation affected the inflammatory systemand regulatedNOproduction in both activated and inactivated macrophages through different regulation mechanisms, depending on irradiation dose.
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참고문헌 (16)
참고문헌 신청
Bjordal JM / 2003 / A systematic review of low level laser therapy with locationspecific doses for pain from chronic joint disorders / Aust J Physiother 49:107~116
Bjordal JM / 2006 / Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials / Photomed Laser Surg 24:158~168
Bortfeld T / 2011 / The physical basis and future of radiation therapy / Br J Radiol 84:485~498
Brenner DJ / 2003 / Cancer risks attributable to low doses of ionizing radiation: assessing what we really know / Proc Natl Acad Sci USA 100:13761~13766
Cheda A / 2004 / Single low doses of X rays inhibit the development of experimental tumor metastases and trigger the activities of NK cells in mice / Radiat Res 161:335~340
Bjordal JM / 2006 / Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials / Photomed Laser Surg 24:158~168
Bortfeld T / 2011 / The physical basis and future of radiation therapy / Br J Radiol 84:485~498
Brenner DJ / 2003 / Cancer risks attributable to low doses of ionizing radiation: assessing what we really know / Proc Natl Acad Sci USA 100:13761~13766
Cheda A / 2004 / Single low doses of X rays inhibit the development of experimental tumor metastases and trigger the activities of NK cells in mice / Radiat Res 161:335~340
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