지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.11
- 수록면
- 111 - 117 (7page)
이용수
초록· 키워드
오류제보하기
The paradigm of immune homeostasis between type-1 helper T cells (Th1) and type-2 helper T cells (Th2) has been extensively examined with respect to infectious diseases, autoimmune diseases, or tumor progression. Such studies have mostly relied on the profiling of cytokines/chemokines using animal studies or cell culture-based in vitro tests. No quantitative analyses have yet been systematically performed to determine the relationship between the various immune parameters in in vivo investigations. Using peripheral blood from 55 chicken husbandry workers or grapevine orchard workers, we obtained data for various immunologic markers as follows: proportion of major immune cell subpopulations, concentrations of plasma immunoglobulin subclasses, and levels of cytokines produced from activated peripheral blood mononuclear cells. Correlational analyses were carried out to examine the association between these parameters. As the IFN-γ:IL-13 ratio was strongly associated with the production levels of IFN-γ, TNF-α, and to the IFN-γ:IL-4 ratio, the IFN-γ:IL-13 ratio could prove to be a valuable monitoring index to examine Th1 or Th2 predominance. IL-17 levels correlated well with those of IFN-γ or TNF-α. Plasma levels of IgG4, a typical IgG subclass expressed upon the occurrence of allergic diseases, strongly correlated with IgG1 levels, suggesting the implication of IgG1 in allergic hyperreactivity. The proportion of cytotoxic T cells correlated significantly with levels of IFN-γ, and the proportion of natural killer T cells correlated well with IL-13 levels. These two cell types are sources for the production of IFN-γ and IL-3 respectively; hence, results of this study might provide potential monitoring markers for cytotoxic T cells or natural killer T cell-mediated immunoreactivity. Overall, the present study provides several putative candidates for the surveillance or prognosis of the in vivo alteration of humoral or cell-mediated immunity.
목차
ABSTRACT
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (31)
참고문헌 신청
Bretscher P / 2019 / On analyzing how the Th1/Th2 phenotype of an immune response is determined : classical observations must not be ignored / Front Immunol 10:1234
Bretscher PA / 2014 / On the mechanism determining the Th1/Th2phenotype of an immune response, and its pertinence to strategies for the preventions, and treatment, of certain infectious diseases / Scand J Immunol 79:361~376
Kidd P / 2003 / Th1/Th2 balance : the hypothesis, its limitations, and implications for health and disease / Altern Med Rev 8:223~246
Lee HL / 2019 / Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinioma in patients treated with transarterial chemoembolization / Sci Rep 9:3260
Asselin-Paturel C / 1998 / Quantitative analyses of Th1, Th2 and TGF-β1 cytokine expression in tumor, TIL and PBL of nonsmall cell lung cancer patients / Int J Cancer 77:7~12
Bretscher PA / 2014 / On the mechanism determining the Th1/Th2phenotype of an immune response, and its pertinence to strategies for the preventions, and treatment, of certain infectious diseases / Scand J Immunol 79:361~376
Kidd P / 2003 / Th1/Th2 balance : the hypothesis, its limitations, and implications for health and disease / Altern Med Rev 8:223~246
Lee HL / 2019 / Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinioma in patients treated with transarterial chemoembolization / Sci Rep 9:3260
Asselin-Paturel C / 1998 / Quantitative analyses of Th1, Th2 and TGF-β1 cytokine expression in tumor, TIL and PBL of nonsmall cell lung cancer patients / Int J Cancer 77:7~12
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Agrobacterium sp.-derived β-1,3-glucan enhances natural killer cell activity in healthy adults : a randomized, double-blind, placebo-controlled, parallel-group study
Nutrition Research and Practice
2017 .02
-
Agrobacterium sp.-derived β-1,3-glucan enhances natural killer cell activity in healthy adults : a randomized, double-blind, placebo-controlled, parallel-group study
Nutrition Research and Practice
2017 .02
-
Induction of IFN-β through both TLR-3? and RIG-I?mediated signaling pathways in canine respiratory epithelial cells infected with H3N2 canine influenza virus
Journal of Microbiology and Biotechnology
2021 .01
-
Association between serum fatty acid composition and innate immune markers in healthy adults
Nutrition Research and Practice
2016 .04
-
Association between serum fatty acid composition and innate immune markers in healthy adults
Nutrition Research and Practice
2016 .04
-
Tyndallized Lactobacillus plantarum HY7712 Restores Whole-Body γ-Irradiation-Impaired Th Cell Differentiation in Mice
Journal of Microbiology and Biotechnology
2017 .01
-
Evaluation of Th1/Th2-Related Immune Response against Recombinant Proteins of Brucella abortus Infection in Mice
Journal of Microbiology and Biotechnology
2016 .01
-
Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms
Journal of Microbiology and Biotechnology
2017 .01
-
Heterologous Expression of Interferon α-2b in Lactococcus lactis and its Biological Activity against Colorectal Cancer Cells
한국미생물·생명공학회지
2021 .01
-
A Homogeneous Immunoassay Method for Detecting Interferon-Gamma in Patients with Latent Tuberculosis Infection
Journal of Microbiology and Biotechnology
2016 .01
-
IFN-λ4 Potently Induces ISG15/USP18-mediated IFN-α Unresponsiveness
한국미생물학회 학술대회논문집
2016 .04
-
Efficient Interleukin-21 Production by Optimization of Codon and Signal Peptide in Chinese Hamster Ovarian Cells
Journal of Microbiology and Biotechnology
2019 .01
-
Single-Cell Genomics for Investigating Pathogenesis of Inflammatory Diseases
Molecules and Cells
2023 .02
-
Cell-Based IL-15:IL-15Rα Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice
Molecules and Cells
2019 .01
-
Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I
Journal of Microbiology and Biotechnology
2018 .01
-
Effects of in vitro vitamin D treatment on function of T cells and autophagy mechanisms in high-fat diet-induced obese mice
Nutrition Research and Practice
2021 .12
-
Effects of in vitro vitamin D treatment on function of T cells and autophagy mechanisms in high-fat diet-induced obese mice
Nutrition Research and Practice
2021 .12
-
Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation
Molecules and Cells
2021 .01
-
Natural Killer Cell Activation by Weissella cibaria JW15 Isolated from Kimchi
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2021 .06
-
Brief guide to senescence assays using cultured mammalian cells
Molecules and Cells
2024 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2021-047-000077831