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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제4호
- 발행연도
- 2015.1
- 수록면
- 448 - 451 (4page)
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In a previous study, we isolated octaphlorethol A (OPA) from Ishige foliacea and evaluated its anti-melanogenesis activity in a murine melanoma cell line. However, the whitening effect and toxicity of OPA have not yet been examined in vivo. Therefore, in this study, we investigated the inhibitory effect of OPA on melanin synthesis and tyrosinase activity in an in vivo zebrafish model. More than 90% of subject embryos survived upon exposure to OPA concentrations below 25 μM, which was not significantly different from the finding in the control group. OPA markedly inhibited melanin synthesis and tyrosinase activity in a concentration-dependent manner.
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참고문헌 (17)
참고문헌 신청
Ando H / 2007 / Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase / J. Invest. Dermatol 127 : 751 ~ 761
Balboa EM / 2013 / In vitro antioxidant properties of crude extracts and compounds from brown algae / Food Chem 138 : 1764 ~ 1785
Cha SH / 2011 / Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish / J. Dermatol 38
Choi TY / 2007 / Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds / Pigment Cell Res 20 : 120 ~ 127
Eisen JS / 1996 / Zebrafish make a big splash / Cell 87 : 969 ~ 977
Balboa EM / 2013 / In vitro antioxidant properties of crude extracts and compounds from brown algae / Food Chem 138 : 1764 ~ 1785
Cha SH / 2011 / Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish / J. Dermatol 38
Choi TY / 2007 / Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds / Pigment Cell Res 20 : 120 ~ 127
Eisen JS / 1996 / Zebrafish make a big splash / Cell 87 : 969 ~ 977
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