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논문 기본 정보

자료유형
학술저널
저자정보
Choi Byeong Min (Department of Pharmaceutical Engineering and Biotechnology, Sunmoon University, Chungnam 31460, Republic of Korea) Kim Minkyeong (Biodiversity Research Department Species Diversity Research Division, National Institute of Biological Resources, Incheon 22689, Korea) Hong Hyehyun (Department of Pharmaceutical Engineering and Biotechnology, Sunmoon University, Chungnam 31460, Republic of Korea) Park Tae-Jin (Department of Pharmaceutical Engineering and Biotechnology, Sunmoon University, Chungnam 31460, Republic of Korea) Kim Changmu (Biodiversity Research Department Species Diversity Research Division, National Institute of Biological Resources, Incheon 22689, Korea) Park Jin-Soo (Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea) Chi Won-Jae (Biodiversity Research Department Species Diversity Research Division, National Institute of Biological Resources, Incheon 22689, Korea) Kim Seung-Young (Department of Pharmaceutical Engineering and Biotechnology, Sunmoon University, Chungnam 31460, Republic of Korea)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.4
발행연도
2024.4
수록면
949 - 957 (9page)
DOI
10.4014/jmb.2311.11021

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There has been a growing interest in skin beauty and antimelanogenic products. Melanogenesis is the process of melanin synthesis whereby melanocytes are activated by UV light or hormone stimulation to produce melanin. Melanogenesis is mediated by several enzymes, such as tyrosinase (TYR), microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1), and TRP-2. In this study, we investigated the effect of Tuber himalayense extract on melanin synthesis in α-melanocyte-stimulating hormone (α-MSH)-treated B16F10 melanoma cells. We confirmed that T. himalayense extract was not toxic to α-MSH-treated B16F10 melanoma cells and exhibited a significant inhibitory effect on melanin synthesis at concentrations of 25, 50, and 100 μg/ml. Additionally, the T. himalayense extract inhibited melanin, TRP-1, TRP-2, tyrosinase, and MITF, which are enzymes involved in melanin synthesis, in a concentration-dependent manner. Furthermore, T. himalayense extract inhibited the mitogen-activated protein kinase (MAPK) pathways, such as extracellular signal-regulated kinase-1/2 (ERK), c-Jun N-terminal kinase (JNK), and p38. Therefore, we hypothesized that various components of T. himalayense extract affect multiple factors involved in melanogenesis in B16F10 cells. Our results indicate that T. himalayense extract could potentially be used as a new material for preparing whitening cosmetics.

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