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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제11호
- 발행연도
- 2015.1
- 수록면
- 1,787 - 1,795 (9page)
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초록· 키워드
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The transition from primary to secondary metabolism in antibiotic-producing Streptomyces correlates with expression of genes involved in stress responses. Consequently, regulatory pathways that regulate specific stress responses are potential targets to manipulate to increase antibiotic titers. In this study, genes encoding key proteins involved in regulation of the osmotic stress response in Streptomyces avermitilis, the industrial producer of avermectins, are investigated as targets. Disruption of either osaBSa, encoding a response regulator protein, or osaCSa, encoding a multidomain regulator of the alternative sigma factor SigB, led to increased production of both oligomycin, by up to 200%, and avermectin, by up to 37%. The mutations also conditionally affected morphological development; under osmotic stress, the mutants were unable to erect an aerial mycelium. In addition, we demonstrate the delivery of DNA into a streptomycete using biolistics. The data reveal that information on stress regulatory responses can be integrated in rational strain improvement to improve yields of bioactive secondary metabolites.
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참고문헌 (23)
참고문헌 신청
Bibb MJ / 2005 / Regulation of secondary metabolism in streptomycetes / Curr. Opin. Microbiol 8 : 208 ~ 215
Bishop A / 2004 / Systematic insertional mutagenesis of a streptomycete genome: a link between osmoadaptation and antibiotic production / Genome Res 14 : 893 ~ 900
Chen Y / 2010 / Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation / Appl. Microbiol. Biotechnol 86 : 19 ~ 25
Colosimo A / 2000 / Transfer and expression of foreign genes in mammalian cells / BioTechniques 29 : 314 ~ 324
Dutta R / 2000 / GHKL, an emergent ATPase/kinase superfamily / Trends Biochem. Sci 25 : 24 ~ 28
Bishop A / 2004 / Systematic insertional mutagenesis of a streptomycete genome: a link between osmoadaptation and antibiotic production / Genome Res 14 : 893 ~ 900
Chen Y / 2010 / Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation / Appl. Microbiol. Biotechnol 86 : 19 ~ 25
Colosimo A / 2000 / Transfer and expression of foreign genes in mammalian cells / BioTechniques 29 : 314 ~ 324
Dutta R / 2000 / GHKL, an emergent ATPase/kinase superfamily / Trends Biochem. Sci 25 : 24 ~ 28
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