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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제1호
- 발행연도
- 2009.1
- 수록면
- 51 - 54 (4page)
이용수
초록· 키워드
오류제보하기
Myxobacteria, Gram-negative soil bacteria, are a well-known
producer of bioactive secondary metabolites. Therefore,
this study presents a methodological approach for the
high-throughput screening of secondary metabolites from
4 wild-type Myxococcus xanthus strains. First, electrospray
ionization mass spectrometry (ESI-MS) was performed
using extracellular crude extracts. As a result, 22 metabolite
peaks were detected, and the metabolite profiling was
then conducted using the m/z value, retention time, and
MS/MS fragmentation pattern analyses. Among the peaks,
one unknown compound peak was identified as analogous
to the myxalamid A, B, and C series. An analysis of the
tandem mass spectrometric fragmentation patterns and
HR-MS identified myxalamid K as a new compound derived
from M. xanthus. In conclusion, LC-MS/MS-based chemical
screening of diverse secondary metabolites would appear
to be an effective approach for discovering unknown
microbial secondary metabolites.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Bino, R. J. / 2004 / Potential of metabolomics as a functional genomics tool / Trends Plant Sci 9 : 418 ~ 424
Frykman, S. / 2006 / Characterization of product capture resin during microbial cultivations / J. Ind. Microbiol. Biotechnol 33 : 445 ~ 453
Gerth, K. / 1982 / The myxovirescins, a family of antibiotics from Myxococcus virescens (Myxobacterales) / J. Antibiot 35 : 1454 ~ 1459
Gerth, K. / 1983 / The myxalamids, new antibiotics from Myxococcus xanthus(Myxobacterales). I. Production, physico-chemical and biological properties and mechanism of action
Jansen, R. / 1983 / Myxalamide A, B, C, and D, eine gruppe homologer antibiotika aus Myxococcus xanthus Mxx12(Myxobacteriales) / Liebigs Ann. Chem 1983 : 1081 ~ 1095
Frykman, S. / 2006 / Characterization of product capture resin during microbial cultivations / J. Ind. Microbiol. Biotechnol 33 : 445 ~ 453
Gerth, K. / 1982 / The myxovirescins, a family of antibiotics from Myxococcus virescens (Myxobacterales) / J. Antibiot 35 : 1454 ~ 1459
Gerth, K. / 1983 / The myxalamids, new antibiotics from Myxococcus xanthus(Myxobacterales). I. Production, physico-chemical and biological properties and mechanism of action
Jansen, R. / 1983 / Myxalamide A, B, C, and D, eine gruppe homologer antibiotika aus Myxococcus xanthus Mxx12(Myxobacteriales) / Liebigs Ann. Chem 1983 : 1081 ~ 1095
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