지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제5호
- 발행연도
- 2008.1
- 수록면
- 913 - 917 (5page)
이용수
초록· 키워드
오류제보하기
The cyclic undecapeptide, cyclosporin A (CyA), is one of the most commonly prescribed immunosuppressive drugs.
It is generated nonribosomally from a multifunctional cyclosporin synthetase enzyme complex by the filamentous fungus Tolypocladium niveum. In order to maximize the production of CyA by wild-type T. niveum (ATCC 34921), each of three culture stages (sporulation culture, growth culture, and production culture) were sequentially optimized.
Among the three potential sporulation media, the SSMA medium generated the highest numbers of T. niveum spores. The SSM and SM media were then selected as the optimal growth and production culture media, respectively.
The addition of valine and fructose to the SM production medium was also determined to be crucial for CyA biosynthesis. In this optimized three-stage culture system, 3% of the spore inoculum generated the highest level of CyA productivity in a 15-day T. niveum production culture, thereby implying that the determination of an appropriate size of T. niveum spore inoculum plays a critical role in the maximization of CyA production.
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참고문헌 (23)
참고문헌 신청
Balaraman, K. / 2006 / Optimization of media composition for the production of cyclosporin A by Tolypocladium species. Indian J. Med / Res 123 : 525 ~ 530
Borel, J. F. / 1983 / Cyclosporin: Historical perspectives. Transplant / Proc 15 (2219)
Borel, J. F. / 1986 / Cyclosporin and its future / Progress in Allergy : 9 ~ 18
Chahal, P. S. / 1992 / Fluorosensor controlled fed-batch production of cyclosporin-A from Beaveria nivea. PhD Thesis. Faculty of Graduate studies / The University of Western Ontario
Chun, G.-T. / 1991 / Comparative studies of physiological and environmental effects on the production of cyclosporine A in suspended and immobilized cells of Tolypocladium in
Borel, J. F. / 1983 / Cyclosporin: Historical perspectives. Transplant / Proc 15 (2219)
Borel, J. F. / 1986 / Cyclosporin and its future / Progress in Allergy : 9 ~ 18
Chahal, P. S. / 1992 / Fluorosensor controlled fed-batch production of cyclosporin-A from Beaveria nivea. PhD Thesis. Faculty of Graduate studies / The University of Western Ontario
Chun, G.-T. / 1991 / Comparative studies of physiological and environmental effects on the production of cyclosporine A in suspended and immobilized cells of Tolypocladium in
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