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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 140 - 146 (7page)
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초록· 키워드
오류제보하기
Cyclosporin, an immunosuppressant, is a representative
group of biologically active secondary metabolites produced by the fungus Tolypocladium inflatum. The
amount and ratio of cyclosporin derivatives in the culture broth are an important factors for the production of
cyclosporin A and the purification in the industrial process. Therefore, we studied the effect of amino acids
and complex organic nitrogen sources using Tolypocladium inflatum mutants on the productivity of
cyclosporin A and the ratio of cyclosporin derivatives. Overproducing mutant YHC-004 having seven times
higher productivity than mother strain's could be obtained through the artificial mutation by UV irradiation.
The concentration and kind of organic nitrogens and amino acids shows the profound effect on the productivity
of cyclosporin A and ratio of cyclosporin derivatives. As a result, it was possible to raise the productivity
and the ratio of cyclosporin A up to 3,430 mg/L and 93% respectively, but on the other hand the other
cyclosporin derivatives decreased less than 2% in the culture broth.
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참고문헌 (20)
참고문헌 신청
ABDEL-FATTAH, Y. R / 2007 / Application of Factorial Experimental Designs for Optimization of CyclosporinA Production by Tolypocladium inflatum in Submerged Culture / Journal
Agathos, S. N / 1986 / Physiological and genetic factors for process development of cyclosporine fermentations / J. Ind. Microbiol 1 : 39 ~ 47
Agathos, S. N / 1987 / The fungal production of cyclosporin / Ann. N.Y. Acad. Sci 506 : 657 ~ 662
Billich, A / 1987 / Enzymatic synthesis of cyclosporin A / J. Biol. Chem 262 : 17258 ~ 17259
Borel, J. F / 1986 / Cyclosporin and its future. in: Cyclosporins, Progress in allergy, vol. 38 / Karger
Agathos, S. N / 1986 / Physiological and genetic factors for process development of cyclosporine fermentations / J. Ind. Microbiol 1 : 39 ~ 47
Agathos, S. N / 1987 / The fungal production of cyclosporin / Ann. N.Y. Acad. Sci 506 : 657 ~ 662
Billich, A / 1987 / Enzymatic synthesis of cyclosporin A / J. Biol. Chem 262 : 17258 ~ 17259
Borel, J. F / 1986 / Cyclosporin and its future. in: Cyclosporins, Progress in allergy, vol. 38 / Karger
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