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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제14권 제2호
- 발행연도
- 2004.1
- 수록면
- 379 - 384 (6page)
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Fibroblast growth factor-2 (FGF-2) is known tomodulate numerous cellular functions in various cell types,including cell proliferation, differentiation, survival, adhesion,migration, and motility, and also in processes such as woundhealing, angiogenesis, and vasculogenesis. FGF-2 regulatesthe expression of several molecules thought to mediate criticalsteps during angiogenesis. This study examines the mechanismsunderlying FGF-2-induced cell migration, using humanumbilical vein endothelial cells (HUVECs). FGF-2 inducedthe nondirectional and directional migration of endothelialcells, which are inhibited by MMPs and plasmin inhibitors,and induced the secretion of matrix metalloproteinase-3(MMP-3) and MMP-9, but not MMP-1 and MMP-2.FGF-2 also induced the secretion of the tissue inhibitor ofmetalloproteinase-1 (TIMP-1), but not of TIMP-2. Also, thepan-PKC inhibitor inhibited FGF-2-induced MMP-9 secretion.It is, therefore, suggested that FGF-2 induces the migration ofcultured endothelial cells by means of increased MMPs andplasmin secretion. Furthermore, FGF-2 may increase MMP-9secretion by activating the PKC pathway.
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참고문헌 (29)
참고문헌 신청
[학술지(
Baramova, E. N / 1997 / Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation 405 : 157 ~ 162
Benbow, U / 1996 / Characterization of the 46-kDa intermediates of matrixmetalloproteinase 3 obtained by site-directedmutation of phenylalanine 83 271 : 10715 ~ 10722
Bikfalvi, A / 1997 / Biological roles of fibroblast growth factor-2 18 : 26 ~ 45
Brooks / 1994 / Requirement of vascular integrin alpha v beta 3 forangiogenesis : 569 ~ 264 571
Baramova, E. N / 1997 / Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation 405 : 157 ~ 162
Benbow, U / 1996 / Characterization of the 46-kDa intermediates of matrixmetalloproteinase 3 obtained by site-directedmutation of phenylalanine 83 271 : 10715 ~ 10722
Bikfalvi, A / 1997 / Biological roles of fibroblast growth factor-2 18 : 26 ~ 45
Brooks / 1994 / Requirement of vascular integrin alpha v beta 3 forangiogenesis : 569 ~ 264 571
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