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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제4호
- 발행연도
- 2016.1
- 수록면
- 784 - 789 (6page)
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초록· 키워드
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We evaluated the synergistic antibacterial effect in combination with the chitosan-ferulic acid conjugate (CFA) and β-lactam antibiotics, such as ampicillin, penicillin, and oxacillin, against methicillin-resistant Staphylococcus aureus (MRSA) using fractional inhibitory concentration (FIC) indices. CFA clearly reversed the antibacterial activity of ampicillin, penicillin, and oxacillin against MRSA in the combination mode. Among these antibiotics, the combination of oxacillin-CFA resulted in a ΣFICmin range of 0.250 and ΣFICmax of 0.563, suggesting that the oxacillin-CFA combination resulted in an antibacterial synergy effect against MRSA. In addition, we determined that CFA inhibited the mRNA expression of gene mecA and the production of PBP2a, which is a key determinant for β-lactam antibiotic resistance, in a dosedependent manner. Thus, the results obtained in this study supported the idea on the antibacterial action mechanism that oxacillin will restore the antibacterial activity against MRSA through the suppression of PBP2a production by CFA.
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참고문헌 (20)
참고문헌 신청
Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72:248~254
Cho YS / 2011 / Preparation, characterization, and antioxidant properties of gallic acidgrafted-chitosans / Carbohydr. Polym 83:1617~1622
De Lencastre H / 1999 / Antibiotic resistance as a stress response:complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin / Microb. Drug Resist 5:163~175
Dutton EK / 2000 / Expression of active monomeric and dimeric nuclease A from the gram positive Streptococcus gordonii surface protein expression system / Protein Expr. Purif 19:158~172
Eom SH / 2014 / The mechanism of antibacterial activity of phlorofucofuroeckol-A against methicillin-resistant Staphylococcus aureus / Appl. Microbiol. Biotechnol 98:9795~9804
Cho YS / 2011 / Preparation, characterization, and antioxidant properties of gallic acidgrafted-chitosans / Carbohydr. Polym 83:1617~1622
De Lencastre H / 1999 / Antibiotic resistance as a stress response:complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin / Microb. Drug Resist 5:163~175
Dutton EK / 2000 / Expression of active monomeric and dimeric nuclease A from the gram positive Streptococcus gordonii surface protein expression system / Protein Expr. Purif 19:158~172
Eom SH / 2014 / The mechanism of antibacterial activity of phlorofucofuroeckol-A against methicillin-resistant Staphylococcus aureus / Appl. Microbiol. Biotechnol 98:9795~9804
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