지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제4호
- 발행연도
- 2017.1
- 수록면
- 694 - 700 (7page)
이용수
초록· 키워드
오류제보하기
Clostridium difficile, which causes pseudomembranous colitis, releases toxin A and toxin B. These toxins are considered to be the main causative agents for the disease pathogenesis, and their expression is associated with a marked increase of apoptosis in mucosal epithelial cells. Colonic epithelial cells are believed to form a physical barrier between the lumen and the submucosa, and abnormally increased mucosal epithelial cell apoptosis is considered to be an initial step in gut inflammation responses. Therefore, one approach to treating pseudomembranous colitis would be to develop agents that block the mucosal epithelial cell apoptosis caused by toxin A, thus restoring barrier function and curing inflammatory responses in the gut. We recently isolated an antimicrobial peptide, Periplanetasin-2 (Peri-2, YPCKLNLKLGKVPFH) from the American cockroach, whose extracts have shown great potential for clinical use. Here, we assessed whether Peri-2 could inhibit the cell toxicity and inflammation caused by C. difficile toxin A. Indeed, in human colonocyte HT29 cells, Peri-2 inhibited the toxin A-induced decrease in cell proliferation and ameliorated the cell apoptosis induced by this toxin. Moreover, in the toxin A-induced mouse enteritis model, Peri-2 blocked the mucosal disruption and inflammatory response caused by toxin A. These results suggest that the American cockroach peptide Peri-2 could be a possible drug candidate for addressing the pseudomembranous colitis caused by C. difficile toxin A.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Harper JW / 1993 / The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases / Cell 75 : 805 ~ 816
Hing TC / 2013 / The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice / Gut 62 : 1295 ~ 1305
Izawa H / 2005 / Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells / Int. J. Oncol 27 : 69 ~ 76
Jiang Y / 2006 / Inhibitory effect of Periplaneta americana extrac t on 3LL lung cancer in mice / Zhongguo Fei Ai Za Zhi 9 : 488 ~ 491
Just I / 1995 / Glucosylation of Rho proteins by Clostridium difficile toxin B / Nature 375 : 500 ~ 503
Hing TC / 2013 / The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice / Gut 62 : 1295 ~ 1305
Izawa H / 2005 / Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells / Int. J. Oncol 27 : 69 ~ 76
Jiang Y / 2006 / Inhibitory effect of Periplaneta americana extrac t on 3LL lung cancer in mice / Zhongguo Fei Ai Za Zhi 9 : 488 ~ 491
Just I / 1995 / Glucosylation of Rho proteins by Clostridium difficile toxin B / Nature 375 : 500 ~ 503
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