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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제3호
- 발행연도
- 2009.1
- 수록면
- 307 - 313 (7page)
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초록· 키워드
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In order to systemically investigate the possibility of using
coxsackievirus B3 (CVB3) to deliver foreign genes in vivo, a
recombinant strain of CVB3 encoding the renilla gene (CVB3-
renilla) was constructed. The recombinant CVB3 resulted
in extensive and transient expression of the renilla protein
within mouse organs, especially the pancreas. The level of
expression was generally dependent upon the viral titer
present. Moreover, the CVB3-renilla strain was completely
attenuated. Interestingly, the recombinant CVB3 vector was
expressed much more strongly in mouse organs than was
a comparable adenoviral vector. The CVB3-renilla strain
did not express the renilla gene in mice with pre-existing
coxsackievirus-specific neutralizing antibodies, but direct
organ-specific administration of the virus during openperitoneum
surgery was able to circumvent this immunity.
This coxsackievirus vector may represent a useful means
for delivering and expressing foreign genes in mouse models
in an acute and extensive fashion.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Anversa, P. / 2006 / Life and death of cardiac stem cells: A paradigm shift in cardiac biology / Circulation 113 : 1451 ~ 1463
Chapman, N. M. / 2000 / Coxsackievirus expression of the murine secretory protein interleukin-4 induces increased synthesis of immunoglobulin G1 in mice / J. Virol 74 : 7952
Douglss, J. T. / 2007 / Adenoviral vectors for gene therapy / Mol. Biotechnol 36 : 71 ~ 80
Esfandiarei, M. / 2007 / Molecular biology and pathogenesis of viral myocarditis / Annu. Rev. Pathol 3 : 127 ~ 155
Halim, S. S. / 2000 / A therapeutic HIV vaccine using coxsackie-HIV recombinants: A possible new strategy / AIDS Res. Hum. Retroviruses 16 : 1551 ~ 1558
Chapman, N. M. / 2000 / Coxsackievirus expression of the murine secretory protein interleukin-4 induces increased synthesis of immunoglobulin G1 in mice / J. Virol 74 : 7952
Douglss, J. T. / 2007 / Adenoviral vectors for gene therapy / Mol. Biotechnol 36 : 71 ~ 80
Esfandiarei, M. / 2007 / Molecular biology and pathogenesis of viral myocarditis / Annu. Rev. Pathol 3 : 127 ~ 155
Halim, S. S. / 2000 / A therapeutic HIV vaccine using coxsackie-HIV recombinants: A possible new strategy / AIDS Res. Hum. Retroviruses 16 : 1551 ~ 1558
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